多药耐药基因1C3435T多态性与癫痫耐药的关联性研究

Association of C3435T Polymorphism in Multidrug Resistance Gene 1 with Refractory Epilepsy

目的:探讨我国癫痫患者P-糖蛋白基因多态性(C3435T)与抗癫痫药物反应性的关联性。方法:采用PCR--RFLP(聚合酶链反应--限制性片段长度多态性分析)的方法对156例癫痫患者外周血进行分型。其中,耐药组癫痫患者85例,有效组癫痫患者71例。结果:耐药组癫痫患者CC基因型21例,占24.70%;有效组癫痫患者CC基因型19例,占26.76%。两组比较无显著差异性。结论:本研究未发现P-gp C3435T基因型与癫痫耐药的关联性。

Objective： To discuss the association between the P-glycoprotein gene polymorphism and the efficacy of epilepsy drug.Methods： Genotypes of the C3435T polymorphism were determined by the polymerase chain reaction restriction fragment length poly-morphism（PCR-RFLP） methods in 156 patients,Including refractory epilepsy group（85） and drug-responsive group（71）.Results： In non responders,21 patients were CC genotype（24.70%）.In responders,19 patients were CC genotype（26.76%）.Conclusion： There is no as-sociation between the P-gp C3435T gene polymorphism and the response to antiepileptic drug treatment in Chinese patient with epilepsy.