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原癌基因Bmi-1在消化道肿瘤研究进展 被引量：2

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摘要 原癌基因Bmi-1(B-cell-specific moloney murine leukemia virus integration site1)是多梳基因家族(polycomb group genes,PcG)中的成员之一,其编码蛋白是一种广泛表达的核蛋白,调节同源盒基因(homeobox-containing genes,Hox)的转录。Bmi-1可以通过INK4a/ARF阻断细胞周期相关蛋白P16Ink4a和P19Arf(人类为P14Arf)抑制细胞增殖的作用,并与C-myc起协同作用参与调节细胞的增殖和分化,成为成体干细胞和肿瘤干细胞的自我更新和分化所必需。Bmi-1在肿瘤细胞表达普遍上调,在肿瘤启始和进展阶段发挥重要作用。近来针对Bmi-1基因的研究已越来越多,本文就Bmi-1与消化道肿瘤关系的研究进展作一综述。
作者 邓辉 黄开红
机构地区 中山大学附属孙逸仙纪念医院消化内科
出处 《岭南现代临床外科》 2011年第3期229-231,共3页 Lingnan Modern Clinics in Surgery
关键词 BMI-1基因 消化道肿瘤 综述
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献21

  • 1Xiao-Ting He,Xiu-Feng Cao,Lv Ji,Bin Zhu,Jin Lv,Dong-Dong Wang,Pei-Hua Lu,Heng-Guan Cui.Association between Bmi1 and clinicopathological status of esophageal squamous cell carcinoma[J].World Journal of Gastroenterology,2009,15(19):2389-2394. 被引量：15
  • 2Da-wei Li,Hua-mei Tang,Jun-wei Fan,Dong-wang Yan,Chong-zhi Zhou,Shu-xia Li,Xiao-liang Wang,Zhi-hai Peng.Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer[J]. Journal of Cancer Research and Clinical Oncology . 2010 (7)
  • 3Hui Wang,Ke Pan,Hua-kun Zhang,De-sheng Weng,Jun Zhou,Jian-jun Li,Wei Huang,Hai-feng Song,Min-shan Chen,Jian-chuan Xia.Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma[J]. Journal of Cancer Research and Clinical Oncology . 2008 (5)
  • 4Alkema MJ,,Wiegant J,Berns A,et al.Characterizationand chromosomal localization of the human protooncogene Bmi-1. Human Molecular Genetics . 1993
  • 5Reinisch C,Kandutsch S,Uthman A,et a1.Bmi-l:aprotein expressed in stem cells,specialized cells andtumors of the gastrointestinal tract. Histology and Histopathology . 2006
  • 6Liu JH,,Song LB,Zhang X,et al.Bmi-1expressionpredicts prognosis for patients with gastric carcinoma. Surgical Oncology . 2008
  • 7Van-Cohuizen M,Frasch M,Wientjens E,et al.Sequence similarity between the mammalian bmi-1 prot o-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature . 1991
  • 8Haupt Y,Alexander WS,Barri G,et al.Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell . 1991
  • 9van Lohuizen M,Verbeek S,Scheijen B,et al.Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell . 1991
  • 10Jacobs JJ,Kieboom K,Marino S,et al.The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature . 1999

二级参考文献27

  • 1Fisichella PM,Patti MG.Esophageal cancer:eMedicine:oncology,2009-03-04.Available from:URL:http:// emedicine.medscape.com/article/277930-overview
  • 2Kuwano H,Kato H,Miyazaki T,Fukuchi M,Masuda N,Nakajima M,Fukai Y,Sohda M,Kimura H,Faried A.Genetic alterations in esophageal cancer.Surg Today 2005;35:7-18
  • 3Haupt Y,Alexander WS,Barri G,Klinken SP,Adams JM.Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.Cell 1991; 65:753-763
  • 4Haupt Y,Bath ML,Harris AW,Adams JM.bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis.Oncogene 1993; 8:3161-3164
  • 5Jacobs JJ,Scheijen B,Voncken JW,Kieboom K,Berns A,van Lohuizen M.Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.Genes Dev 1999; 13:2678-2690
  • 6Jacobs JJ,Kieboom K,Marino S,DePinho RA,van Lohuizen M.The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.Nature 1999; 397:164-168
  • 7Park IK,Qian D,Kiel M,Becker MW,Pihalja M,Weissman IL,Morrison SJ,Clarke MF.Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.Nature 2003; 423:302-305
  • 8Molofsky AV,Pardal R,Iwashita T,Park IK,Clarke MF,Morrison SJ.Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.Nature 2003;425:962-967
  • 9Molofsky AV,He S,Bydon M,Morrison SJ,Pardal R.Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.Genes Dev 2005; 19:1432-1437
  • 10Beà S,Tort F,Pinyol M,Puig X,Hernández L,Hernández S,Fernandez PL,van Lohuizen M,Colomer D,Campo E.BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.Cancer Res 2001; 61:2409-2412

共引文献14

同被引文献26

  • 1杨玲,李连弟,陈育德,D.M.Parkin.中国2000年及2005年恶性肿瘤发病死亡的估计与预测[J].中国卫生统计,2005,22(4):218-221. 被引量：336
  • 2Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer, 2006,6(11):846-856.
  • 3Guo BH, Feng Y, Zhang R, et al. Bmi-1 promotes invasion and metastasis,and its elevated expression is eorrelated with an advanced stage of breast cancer. Mol Cancer, 2011,10(1):10.
  • 4Sanchez-Beato M, Sanchez E, Garcia JF, et al. Abnormal PcG protein expression in Hodgkin s lymphoma. Relation with E2F6 and NFκB transcription factors. J Pathol, 2004,204(5):528-537.
  • 5Sparmann A, Van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer, 2006,6(11):846.
  • 6Goebl M G. The bmi-1 and mel-18 gene products define a new family of DNA-binding proteins involved in cell proliferation and tumorigenesis cell, 1991,66(4):623.
  • 7Guo WJ, Datla S, Band V, et al. Mel-18 a polycomb group protein,regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproleins.Mol Biol Cell, 2007,18(2):536-546.
  • 8Guo WJ, Zeng MS, Yadav A, et al. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down regulating Akt activity in breast cancer cells. Cancer Res, 2007,67(11):5083-5089.
  • 9Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer [J]. Gastroenterology, 2013, 144 (6) : 1252-1261.
  • 10McNutt M. Cancer immunotherapy [J]. Science, 2013, 342 (6165): 1417.

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岭南现代临床外科
2011年 第3期

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