女性精神分裂症伴高泌乳素血症患者泌乳素水平观察分析

Observation and analysis of prolactin level of female patients with schizophrenia and hyperprolactinemia

目的探讨女性精神分裂症伴有高泌乳素血症患者后泌乳素水平变化。方法选择符合中国精神疾病分类与诊断标准(CCMD-2-R)关于精神分裂症的诊断标准,同时符合高泌乳素血症的诊断标准的患者130例分两组进行利培酮和阿立哌唑治疗,用化学发光法在治疗前后同时对患者组和对照组泌乳素水平进行测定分析。结果治疗后与治疗前比较,对照组血清泌乳素水平无变化;利培酮组患者的血清泌乳素水平显著升高,比较差异有统计学意义(P<0.01);阿立哌唑组患者的血清泌乳素水平无明显升高,比较差异无统计学意义(P>0.05)。结论治疗女性精神分裂症患者时,要充分考虑抗精神病药物对其生理功能的影响。选择对泌乳素影响小的抗精神病药物是关键。

Objective To investigate the influence of antipsychotics in the prolactin level changes of the female schizophrenic patients with hyperprolactinemia.Methods We selected the diagnostic criteria which was consistent with CCMD-2-R on of schizophrenia also meeting hyperprolactinemia,130 patients were divided into two groups for patients with risperidone and aripiprazole treatment,then we used chemiluminescence method before and after treatment,and the prolactin levels of control group and patient group were measured and analyzed.Results Compared the result before and after treatment,the serum prolactin level of the control group did not change;the serum prolactin levels of risperidone group were significantly increased（P0.01）;and the serum prolactin levels of aripiprazole group were not increased significantly（P0.05）.Conclusion When treating female patients with schizophrenia,we should consider the physiological function of antipsychotic drugs.And it is the key that choosing antipsychotic drugs with little effect on prolactin.