摘要
目的通过贴敷式头部亚低温不同时间窗对新生仔兔HIBD(缺血缺氧性脑病)治疗前后血中NSE(神经元特异性烯醇化酶)的测定,揭示贴敷式头部亚低温对新生仔兔HIBD有保护作用。方法采用酶联免疫法测定不同时间窗时间的血清中NSE。贴敷式头部亚低温实施6h治疗。结果HIBD后不同时间窗组及假手术组(正常组)组间比较,血清中NSE含量有显著差异(P〈0.01),经q检验进行两两比较发现,HIBD后3h组NSE含量与正常组未见显著差异(P〉0.05),而HIBD后其他组与正常组间均有显著性差异。结论贴敷式头部亚低温对缺血缺氧性脑病有保护作用;HIBD后不同时间窗均有脑保护作用,但HIBD后3h组脑保护作用最强。
Objective To explore the protective effect of sticking--type head cooling, by measuring the content of the NSE in different time windows of cephalic--applied sub--hypothermia in the HIBD therapy in newborn rabbits. Methods a cephalic-- applied sub-- hypothermia was administered to new- born rabbits for 6 hours, while gauging the NSE concentration in serum in different time windows by ELISA (enzyme linked immunosorbent assay). Results There is a significant difference in NSE concentration between false--operational group(the normal group) and diverse time--window groups (P〈 0.01 ). No significant difference was detected in the NSE concentration between the normal group and the three--hour--after--HIBD group by Q Test (P〉0.05), whereas other post--HIBD groups did have significant differences from the normal group. Conclusions Cephalic--applied sub--hypothermia contrib- uted to the protection of HIBD, that carries out its function in different time windows,among those the three--hours being the most powerful one.
出处
《神经疾病与精神卫生》
2011年第3期268-270,共3页
Journal of Neuroscience and Mental Health
关键词
磷酸丙酮酸水含酶
贴敷式头部亚低温
NSE
脑保护
时间窗
Phosphopyruvate hydratase
Cephalic--applied sub--hypothermia
NSE
Brain protection
Time windows