期刊文献+

吸烟及非吸烟肺纤维化患者C-反应蛋白的变化 被引量:4

下载PDF
导出
摘要 目的探讨吸烟对肺纤维化患者和C-反应蛋白(CRP)的影响。方法选取本院收治的吸烟肺纤维化患者33例(吸烟组)及非吸烟肺纤维化患者27例(非吸烟组),分别检查2组临床表现、动脉血气(ABG)、血常规、肺功能及胸部高分辨CT(HRCT),采用散射比浊法测定2组CRP水平并进行比较分析。结果吸烟组出现严重低氧血症,且多表现为中重度限制性通气功能障碍,CRP水平也较非吸烟组明显上升。结论吸烟能引发炎性反应,使CRP水平明显上升,最终导致肺纤维化的形成。
出处 《河北医药》 CAS 2011年第14期2101-2102,共2页 Hebei Medical Journal
基金 河北省医学科学研究重点课题计划(编号:20090266)
  • 相关文献

参考文献7

  • 1丘韶校,徐平,宋卫东.特发性肺纤维化的研究进展[J].罕少疾病杂志,2009(2):54-57. 被引量:11
  • 2中华医学会呼吸病学分会.特发性肺问质纤维化诊断和治疗指南(草案).中华结核和呼吸杂志,2002,25(7):388-388.
  • 3Hammond BC, Ancrbauch O, Kiman D, et al. Effects of cigarette smoking on dogs. Design of experiment, mortality, and findings in lung parenehy- ma. Arch Environ Health, 1970,21:740.
  • 4丁文柏.特发性肺问质纤维化的治疗现状[J].实用医学进修杂志,2008,36(1):10-14. 被引量:10
  • 5Baum gartner KB, Samet JM, Stidley CA, et al. Cigarette smoking a risk factor for idiopathic pulmonary fibrosis. Am J Respir Crit Care Med, 1997,155:242-248.
  • 6张劲农,汪铮,施维,王小溶,赵婷婷,向敏,付薇.己酮可可碱诱导吸烟肺纤维化的机制[J].中国病理生理杂志,2009,25(2):333-337. 被引量:6
  • 7Reny JL, Vuagnat A, Rant C, et al. Diagnosis and follow-up of infections in intensive care patients : value of C-reactive protein compared with other clinical and biological variables. Am J Resplr Cr/t Care Med,2002,30: 529-535,.

二级参考文献37

  • 1吕长俊,高美华,王晓芝.实验性肺纤维化相关基因的表达谱研究[J].中国病理生理杂志,2004,20(7):1297-1298. 被引量:5
  • 2施维,张劲农.Th1/Th2炎症极化与肺气肿和肺纤维化[J].国际呼吸杂志,2007,27(7):551-553. 被引量:5
  • 3Wright JL, Churg A. A model of tobacco smoke - induced airflow obstruction in the guinea pig[ J]. Chest, 2002,121 (5 Suppl) :188S - 191S.
  • 4Elias JA, Kang MJ, Crouthers K, et al. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice [ J ]. Proc Am Thorac Soc, 2006,3 (6) :494 - 498.
  • 5Ma B, Kang M J, Lee CG, et al. Role of CCR5 in IFN - gamma - induced and cigarette smoke - induced emphysema[J]. J Clin Invest, 2005,115(12):3460-3472.
  • 6Baumgartner KB, Samet JM, Stidley CA, et al. Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis [J]. Am J Respir Crit Care Med, 1997,155(1):242 - 248.
  • 7Lukacs NW, Hogaboam C, Chensue SW, et al. Type 1/ type 2 cytokine paradigm and the progression of pulmonary fibrosis[ J]. Chest, 2001,120( 1 Suppl) :5S - 8S.
  • 8Shimizu Y, Kuwabara H, Ono A, et al. Intracellular Th1/Th2 balance of pulmonary CIM ( + ) T cells in pa- tients with active interstitial pneumonia evaluated by serum KL - 6 [ J ]. Immunopharmacol Immunotoxicol, 2006,28 (2) :295 -304.
  • 9Kunkel SL, Chensue SW, Lukacs N, et al. Cytokine phenotypes serve as a paradigms for experimental immune - mediated lung diseases and remodeling [ J ]. Am J Respir Cell Mol Biol, 2003,29(3 Suppl) :S63 -S66.
  • 10Kudaeva OT, Goiman EV, Lykov AP, et al. Effects of preparations modifying Th1/Th2 ratio on the incidence of clinical variants of chronic graft - versus - host reaction [J]. Bull Exp Biol Med, 2005,140(3) :338 -340.

共引文献32

同被引文献41

  • 1冯兴中.DME方法在中医药临床研究中运用的再思考[J].中华中医药杂志,2009,24(S1):8-10. 被引量:2
  • 2王玉,李曙芳,李海峰,冷静.脉冲震荡法测定吸烟者肺功能分析[J].临床肺科杂志,2007,12(1):40-41. 被引量:2
  • 3杨岫岩.在临床流行病学的基础上谈循证医学[J].中国实用内科杂志,2007,27(10):806-808. 被引量:8
  • 4Raghu G.Collard HR. EganJ J. et al. An official ATS/ERS/JRS/ ALA T statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management[J]. AmJ Respir Crit Care Med , 2011.183 (6) : 788-824.
  • 5Oda K. Ishimoto H. Yatera K. et al. High-resolution CT scoring system-based grading scale predicts the clinical outcomes in patients with idiopathic pulmonary fibrosis[J]. Respir Res.2014.15:10.
  • 6A TS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. A TS statement: guidelines for the six-minute walk test[J]. AmJ Respir Crit Care Med , 2002.166 (1) : 111-117.
  • 7Chilosi M. Poletti V. Rossi A. The pathogenesis of COPO and IPF:Oistinct horns of the same devil?[J]. Respir Res.2012. 13(1):3-9.
  • 8Cottin V. Nunes H. Brillet PY. et al. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity[J]. Eur RespirJ .2005.26(4) :586-593.
  • 9Tasaka Sv Mizoguchi Kv Funatsu Yv et al. Cytokine profile of bronchoalveolar lavage fluid in patients with combined pulmonary fibrosis and emphysema, Respirology , 2012,17 (5) :814-820.
  • 10Jankowich MO. Rounds SI. Combined pulmonary fibrosis and emphysema syndrome: a review[J]. Chest. 2012 .141 (1) : 222- 231.

引证文献4

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部