吗啡控释剂口服和经直肠途径治疗癌痛的疗效分析

Comparison the effectiveness and adverse reaction of oral and rectal controlled-release morphine in cancer pain treatment

目的:比较口服、经直肠两种给药途径使用硫酸吗啡控释片治疗癌痛的疗效和不良反应。方法:将中重度癌痛患者81例随机分为A组41例口服给药,B组40例经直肠给药,比较两组的止痛效果和不良反应发生率。结果:A组和B组的疼痛缓解率分别为90.2%(37/41)和92.5%(37/40),结果差异无统计学意义(P>0.05);不良反应发生率除呼吸抑制外,其余不良反应发生率均有差异,且差异有统计学意义(P<0.05)。结论:口服硫酸吗啡控释片和直肠使用吗啡控释剂的止痛疗效相近;但后者的不良反应发生率明显低于前者。

Objective：To compare the effects and adverse reaction of controlled-release morphine in cancer pain treatment per oral and rectum.Methods：In 81 patients with severe cancer pain were randomly divided into A group of 41 cases of oral administration,B group of 40 patients with rectal administration,the analgesic effects were compared and the incidence of adverse reactions.Results：A group and B group of the pain relief rates were 90.2%（37/41） and 92.5%（37/40）,the result was no significant difference（P〉0.05）;incidence of adverse reactions in addition to respiratory depression.There were other differences between the incidence rate of adverse reactions,and the difference was statistically significant（P〈0.05）.Conclusion：Oral morphine sulfate controlled-release tablets and controlled-release morphine dose of rectal pain with similar efficacy;but the latter’s adverse reactions are significantly lower than the former.