糖化血红蛋白与血糖的相关性分析及其对糖尿病诊断敏感性探讨

To analysis the correlation of glycated hemoglobin and blood glucose and investigate the sensitivity of glycated hemoglobin in diagnosis of diabetes

目的:行糖化血红蛋白(HbA1c)与空腹血糖(FPG)、餐后2h血糖(2hPG)相关性分析,探讨其在糖尿病(DM)诊断中的价值。方法:同时测定150例门诊就诊者FPG、HbA1c、2hPG,将HbA1c按不同切点分组计算各自对DM诊断的灵敏性及特异性。结果:150例就诊患者中确诊109例DM患者,其FPG、HbA1c、2hPG与非DM患者组比较显著增高(P<0.01);DM组中,HbA1c与FPG、2hPG正相关;HbA1c对DM诊断的灵敏性较FPG好;HbA1c对DM诊断的最佳切点为6.5%。结论:FBG的波动性较大,2hPG检查繁琐,HbA1c测定对DM的诊断有一定价值及优势。

Objective：To analyze the correlation among glycated hemoglobin（HbA1c） and fasting plasma glucose（FPG） and postprandial 2 h blood glucose（2 h PG）,then exploring the value of HbA1c in diagnosis of diabetes.Methods：To determine the FPG,2 h PG,HbA1c for 150 cases of outpatients.Then the patients were divided into 3 groups by different hemoglobin concentration,calculating the sensitivity and specificity for diagnosis of diabetes in 3 groups severally.Results：109 cases were diagnosed DM.FPG,HbA1c and 2 h PG in DM patients were significantly higher（P〈0.01） comparing with the non-DM patients.HbA1c had positive correlation with FPG and 2 h PG.The sensitivity of HbA1c was better than the FPG in diagnosis of diabetes and the best concentration was 6.5%.Conclusion：The FBG is fluctuant and 2 h PG is cumbersome in detecting,so there is value and advantages for HbA1c in diagnosis of diabetes.