马来酸曲美布汀治疗胃食管返流病的临床疗效观察

The Observation of Clinical Effect of the Trimebutine Maleate on Gastroesophageal Reflux Disease

目的:观察马来酸曲美布汀治疗胃食管返流病的临床疗效。方法:选取我院2009年3月-2011年3月收治的胃食管返流病患者52例,随机分为治疗组(马来酸曲美布汀+PPI)和对照组(PPI),每组各26例,疗程均为4周,治疗结束后通过胃镜结果进行疗效观察。结果:治疗组26例中,显效18例,有效6例,总有效率为92.3%;对照组26例中,显效12例,有效8例,总有效率为76.9%。两组比较差异显著(P<0.05)。结论:马来酸曲美布汀治疗胃食管返流病效果理想,值得临床推广使用。

Objective：To observe the efficacy of trimebutine maleate in patients with gastroesophageal reflux disease（GERD）.Methods：A total of 52 patients with GERD were enrolled in this study and divided into treatment group（26 cases）and control group（26 cases）.The patients in treatment group received trimebutine maleate and proton pump inhibitors（PPI）for 4 weeks.The patients in control group received PPI for 4 weeks.Results：18 cases were markedly effective and 6 cases were effective in 26 patients of treatment group,the total effective rate was 92.3%.12 cases were markedly effective and 8 cases were effective in 26 patients of control group,the total effective rate was 76.9%.Compared to the control group,the effect of trimebutine maleate and PPI on GERD was significant difference（P0.05）.Conclusion：The effect of trimebutine maleate in the treatment of gastroesophageal reflux disease is satisfactory.