低分子肝素钠治疗慢性阻塞性肺疾病急性加重期的疗效观察

Efficacy of Low Molecular Weight Heparin Treatment of Chronic Obstructive Pulmonary Disease with Acute Exacerbation

目的:探讨低分子肝素钠在慢性阻塞性肺疾病急性加重期(AECOPD)中的应用。方法:66例AECOPD患者随机分为治疗组与对照组。两组患者均予常规治疗,治疗组患者加用低分子肝素钠5 000U皮下注射,1次/12h,治疗10d后复查患者动脉血气分析和肺功能。结果:与对照组相比,治疗组动脉血气指标明显改善,而且治疗组与对照组治疗后FEV1比较有显著性差异(P<0.05)。结论:慢性阻塞性肺疾病急性发作期加用低分子肝素钠可明显提高临床疗效,可以推广使用。

Objective：To investigate the low molecular weight heparin in patients with chronic obstructive pulmonary disease with acute exacerbation（AECOPD）in the application.Methods：66 patients with AECOPD were randomly divided into treatment group and control group.On the basis of conventional treatment,control group was treated with low molecular weight heparin plus 5 000U subcutaneously every 12 hours.After 10 days＇treatment arterial blood gas analysis and pulmonary function were retested.Results：Compared with the control group,arterial blood gas of treatment group were significantly improved.After treatment FEV1 of the treatment group was significantly different compared with the control group（P0.05）.Conclusion：Chronic obstructive pulmonary disease with acute exacerbation of low molecular weight heparin plus can significantly improve the clinical efficacy,so it can be widely used.