TGFβ1-509C/T基因多态性与不同中医证型胃癌关系的研究

Relationship Between TGFβ1-509C/T Gene Polymorphism and Traditional Chinese Medical Syndrome Patterns in Gastric Cancer

【目的】研究中国人TGFβ1-509C/T基因多态性与不同病理类型及中医证型胃癌遗传易感性的关系及其对胃癌患者预后的影响。【方法】采用限制性长度片段多态性(RFLP)对648例胃癌及781例正常对照进行TGFβ1-509位点基因分型,分析不同证型及病理学特点的胃癌发病风险。【结果】携带TGFβ1-509 C等位基因(CT/CC)发生胃癌的风险较TT基因型显著降低(OR=0.66,P<0.001),且与肠型胃癌(OR=0.65,P<0.001)及实证型胃癌(OR=0.57,P<0.001)显著相关。【结论】TGFβ1-509C/T基因多态性降低胃癌的发病风险,且与病理类型及中医证型等临床病理学特征有关。

Objective To investigate the relationship of transforming growth factor β1（TGFβ1）-509C/T gene polymorphism with pathological classification and traditional Chinese medical syndrome patterns in gastric cancer patients,and to explore the prognostic factors of gastric cancer.Methods A large population-based case-control study among Chinese was carried out in 648 gastric cancer patients and 781 healthy volunteers.Polymorphism in TGFβ1-509 was analyzed by restriction fragment length polymorphism（RFLP）.The risk factors of gastric cancer patients with different syndrome patterns and pathological classification were analyzed.Results Compared with the TT genotype,C carriers（CT/CC）had a decreased risk of gastric cancer（OR=0.66,P0.001）.The results of stratified analysis showed that C carriers were significantly associated with intestinal type of gastric cancer（OR=0.65,P0.001）,and with sthenia syndrome of gastric cancer（OR=0.57,P0.001）.Conclusion TGFβ1-509C/T gene polymorphism is correlated with pathological classification and traditional Chinese medical syndrome patterns in gastric cancer patients,and indicates low risk of gastric cancer.