银屑病患者血清总胆汁酸水平及肝炎病毒感染状态的研究

Study of serum total bile acid levels and the status of hepatitis virus infection in patients with psoriasis

为了探讨银屑病患者肝功能状态 ,采用ELISA法检测了70例银屑病患者血清总胆汁酸(TBA)水平及乙、丙型肝炎病毒感染状况。结果显示 :对照组TBA为4.0±2.3μmol/L,银屑病组为12.7±4.5μmol/L ,较对照组显著增高(P<0.05) ;银屑病组24例有乙、丙型肝炎病毒感染者TBA水平显著高于38例无肝炎病毒感染者(P<0.01)。PCR检测证实了银屑病患者血清中存在乙、丙型肝炎病毒复制。本研究提示 ,银屑病患者肝功能损害可能与乙、丙型肝炎病毒感染有关。

In order to study the status of liver function in patients with psoriasis, the serum levels of total bile acid (TBA) and status of hepatitis B, C virus infection were determined using ELISA in 70 patients with psoriasis. The results showed that the serum levels of TBA were 4.0±2.3μmol/L in normal controls and 12.7±4.5μmol/L in the psoriatic group which was significantly higher than the normal controls (P< 0.05). The level of TBA in 24 psoriatic patients infected with hepatitis B, C virus was significantly higher than that in 24 patients without hepatitis virus infection (P< 0.01). The results of PCR (polymerase chain reaction) for detecting HBV DNA and HCV RNA proved active viral replication in some psoriatic patients. The above data indicate that impaired liver function in psoriatic patients may be related to hepatitis B and C virus infection.