UBIO治疗对急性CO中毒后迟发性脑病血清自由基水平的影响

Change of Serum Free Radical in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Posioning Treated by UBIO

目的：探讨紫外线照射充氧自血回输治疗对急性一氧化联中毒后迟发性脑病患者血清自由基的影响。方法：随机对44例患者进行治疗前后4项自由基指标测定，并与未治疗的正常人对比观察。结果：患者组血清水溶性脂质过氧化物（WSFS）和过氧化脂质（LPO）明显增高，维生素E（VE）和谷胱甘肽过氧化物酶（GPX）明显降低，与对照组比较有显著性差异（P＜0．01）。治疗前后WSFS、LPO明显下降（P＜0．01），见明显增加（P＜0．01），而GPX也有一定程度的增加（P＞0．05）。结论：提示紫外线照射充氧自血回输治疗有调整自由基代谢的作用。

Objective: To explore the change of serum free radical in peients with delayed encephalopath after acute carbon monoxide poisoning (DEACMP) who were treated by ultraviolet blood irradiatior and oxygenation (UBIO) Methwh: The levels of serum lipid peroxides (LPO), waersolube fluorescence substance (WSFS), glutathione peroxidase (GPX) and vitamine E (VE) werw studied among 44 patients with DEACMP and 38 healthy adults, Results: LPO and WSFS were significanily higher, and GPX and VE lower in ghents than in controls, LPO WSFS were siedcantly lower, VEhgher, and GPX had a little more inceasing (P > 0.05) aller betment than We.Conclusion: ffe treatmnt of UBlO Plays a cehan role in reghating the ndcal metahasm.