染色体多态性与复发性流产关系的探讨

Association between chromosome polymorphism and recurrent spontaneous abortion

目的探讨染色体多态性与复发性流产关系。方法对538对(1 076例)复发性流产及271对(542例)无生殖异常夫妇行染色体核型分析。结果复发性流产组(RSA组)染色体多态性126例,占全部受检者的11.71%,明显高于正常组染色体多态性发生率2.58%,(P<0.01)。染色体多态性中1、9、16号染色体次缢痕增长检出49例,D/G组染色体短臂和随体区延长31例,Y染色体多态性25例,9号染色体臂间倒位21例,RSA组各类染色体多态性检出率均高于正常组的发生率(P<0.05)。随着流产次数增加,染色体多态性检出率增加。结论染色体多态性与复发性流产有相关性。

Objective To study the relationship between chromosome polymorphism and recurrent spontaneous abortion.Method Karyotype analysis of chromosomes of 538（1076 cases）couples with recurrent spontaneous abortion and 271（542 cases）couples with normal reproduction were carried out.Results There were 126 cases（11.71%） with chromosome polymorphism in recurrent spontaneous abortion group,the ratio was higher than that of the normal reproduction group（2.58%）,P〈0.01.Chromosomal polymorphism,including 49 cases with the SC region lengthened of chromosome 1,9 and 16,31 cases with the short arm lengthened of chromosome D/G group,25 cases with Y chromosome polymorphism,and 21 cases with inv（9） were observed.Every type of chromosomal polymorphism has higher detection rate in RSA group than in control group.With the times of recurrent spontaneous abortion increased,the rate of chromosome polymorphism detected increased.Conclusion Chromosome polymorphism is related to recurrent spontaneous abortion.