237例新生儿败血症的病原分布及耐药性分析

Analysis of pathogen bacteria in 237 neonatal septicemia cases and antibiotic resistance

目的了解近年本地区新生儿败血症病原学及细菌耐药状况,用以指导临床治疗。方法对2006年5月至2010年4月收治的237例病例的血液进行培养,并对分离的菌株进行鉴定和药敏试验。结果革兰阳性菌为主要病原菌,排名前3位的病原菌分别是:表皮葡萄球菌(48.52%)、人葡萄球菌(16.03%)、凝固酶阴性葡萄球菌(10.13%)。对培养出的革兰阳性菌最敏感的抗生素是万古毒素、阿米卡星,对培养出的革兰阴性菌最敏感的抗生素是丁胺卡那霉素、亚胺培南。结论本地区新生儿血培养病原菌以革兰阳性菌为主,耐药菌株较多,临床医师应根据细菌鉴定及药敏试验选择敏感药物治疗。

Objective To investigate the composition of pathogenic bacteria in neonatal septicemia and the antimicrobial resistance of these bacteria in this region in recent years and guide the clinical treatment.Method 237 blood samples of neonatal septicemia cases from May 2006 to April 2010 in our hospital were cultured,the isolated strains were identified and their resistance to antibiotics was tested.Result Gram-positive fungi were the main pathogens.The predominant strains were Staphylococcus epidermidis（48.52%）,Staphylococcus hominis（16.03%）,coagulase negative Staphylococcus（10.13%）,respectively.Gram-positive fungi were most sensitive to Vancomycin and Amikacin,while Gram-negative fungi were sensitive to Amikacin sulfate and Imipenem.Conclusion Gram-positive fungus is the main pathogenic bacterium in neonatal septicemia in the region at present.There are increasing quantity of drug-resistant pathogens.The identification of bacteria and drug sensitive test are helpful to clinical therapy.