胰岛素、甘油三酯、血糖对糖尿病患者血浆内皮素的影响

Effect of insulin, triglyceride and blood glucose on plasma endothelin in diabetic patients

目的 探讨糖尿病患者血浆内皮素的影响因素。方法 对照组４３ 人，糖尿病组４５例，测定空腹及早餐后２ 小时的内皮素、胰岛素、甘油三酯、胆固醇、血糖。计算体重指数。结果 糖尿病组内皮素比对照组显著性增高（ Ｐ＜０ ．０１）。糖尿病组：空腹、餐后的内皮素与胰岛素正相关（ Ｐ＜０．０５ ，Ｐ＜ ０．０１）。空腹内皮素与甘油三酯无显著性相关，餐后内皮素与甘油三酯正相关（ Ｐ＜ ０ ．０１） 。空腹、餐后内皮素与血糖正相关（ Ｐ＜ ０．０１） 。空腹、餐后内皮素与胆固醇均无显著性相关。内皮素与体重指数无显著性相关。结论 糖尿病患者血浆内皮素比健康人增高。胰岛素、甘油三酯、血糖是刺激糖尿病患者血浆内皮素增高的重要因素。餐后上述三种因素对糖尿病患者血浆内皮素的作用增强。

Objective To study the influential factors of plasma endothelin (ET) in patients with diabetes mellitus (DM). Methods The plasma concentrations of ET, insulin (Ins), triglyceride (TG), total cholesterol (TC) and blood glucose (BG) were measured in control group (43 subjects) and DM group (45 cases) both on fasting and two hours after breakfast. Bodymassindex(BMI)was also calculated. Results ET of DM group showed significant elevation as compared with that of control group (P<0.01). In DM group fasting and postprandial ET and Ins were positively correlated (P<0.05, P<0.01). Fasting ET and TG showed no significant correlation, but postprandial ET and TG were positive correlated (P<0.01). Both fasting and postprandial ET were positively correlated (P<0.01) with BG. Both fasting and postprandial ET showed no significant correlation with TC. ETandBMIrevealedno significant correlation. Conclusion The plasma ET concentration in DM patients is higher than that in health persons. Ins, TG and BG are important factors that cause plasma ET elevation in DM patients. The above three factors elevate postprandial plasma ET in patients with DM.