大鼠颅脑损伤后动、静脉血和肺冲洗液中组胺水平的改变

Study on the changes in histamine level in arterial and venous blood and in broncheoalveolar lavage fluid from rats with head trauma

目的 研究颅脑损伤后血液和肺部组织胺（ 组胺） 水平的改变。方法 用荧光测定法检测颅脑损伤大鼠动、静脉血和肺泡冲洗液中组胺水平。结果 颅脑损伤大鼠肺湿重和心肺系数均明显高于对照组，其动、静脉血和肺泡冲洗液的组胺水平分别比对照组升高１ ．６８ 、１ ．５３ 和２ ．２７ 倍；而且肺泡冲洗液的白蛋白含量比对照组高７．２４ 倍。结论 血液和肺泡冲洗液中组胺水平的升高很可能与颅脑损伤大鼠肺水肿的发生密切相关，提示组胺可能是导致神经源性肺水肿（ｎｅｕｒｇｅｎｉｃ ｐｕｌｍｏｎｒｙ ｅｄｅｍａ，ＮＰＥ）的重要因素之一。

Objective To study the changes of histamine levels in blood and pulmonary from the rats with head trauma (HT). Methods Histamine levels in arterial and venous blood and in broncheoalveolar lavage fluid (BALF) from HT rats were determined by fluorophotometry. Results The lung weight and heart lung index in HT rats were increased obviously in comparison with normal control. The histamine levels in arterial blood, venous blood and BALF were 1.68, 1.53 and 2.27 times higher than those of control respectively. And the albuminous amounts in BALF were 7.24 times higher than that in control group. Conclusion The increase of histamine levels in blood and BALF may be closely related to the occurrence of pulmonary edema in HT rats, and histamine might be one of the important factors which lead to the production of neurogenic pulmonary edema.