卵巢早衰患者骨量变化的相关研究

The Correlation Research of Bone Density on Women with Premature Ovarian Failure

目的探讨特发性卵巢早衰(POF)患者的骨量变化及其影响因素。方法选择特发性POF患者42例,对照组健康女性60例,测定2组的体质量指数、血清雌二醇(E2)等性激素水平及腰椎、股骨颈骨密度,比较2组骨密度值,并对影响POF患者骨量变化的相关因素进行分析。结果 POF患者的腰椎骨密度为0.92g/cm2,股骨颈骨密度为0.87g/cm2,显著低于对照组(P<0.05)。POF患者的腰椎及股骨颈骨密度与年龄、体质量指数呈显著正相关(P<0.05),与雌激素缺乏时间及血清促卵泡素(FSH)水平呈显著负相关(P<0.05),与初潮年龄及血清黄体生成素(LH)水平无显著相关性。E2水平与腰椎骨密度呈显著正相关,与股骨颈骨密度无明显相关性。结论特发性POF患者骨密度降低,与年龄、体质量指数、雌激素缺乏时间、FSH水平等因素有关,早期的综合治疗将有益于减少POF患者的骨量丢失。

Objective To evaluate the change of bone density and its associated factors in women with premature ovarian failure （POF）.Methods 42 patients with POF undergoing bone mineral density （BMD） were selected,compared to 60 women paired by age whose menstrual cycles were regular.The associated factors with BMD of POF patients were analyzed.Results In women with POF,the mean bone mineral density was 0.92 g/cm2 at the lumbar spine and 0.87 g/cm2 at the neck of femur,both of which were significantly lower than the control group （P0.05）.The BMD at lumbar spine and neck of femur of POF patients presented highly positive correlation with age and body mass index （BMI）,and negative correlation with duration of estrogen deficiency and serum follicle-stimulating hormone （FSH） level.There was no significant correlation with age of menarche and serum luteinizing hormone （LH） level.Serum estradiol （E2） presented positive correlation with BMD of lumbar spine and no significant correlation with BMD of neck of femur.Conclusion Women with POF have a decrease in lumbar spine and femoral bone density.Age,BMI,duration of estrogen deficiency and FSH were associated with BMD.Early comprehensive therapy will be beneficial to prevent bone loss in POF patients.