人参皂苷对免疫抑制小鼠T细胞亚群(CD4^+/CD8^+)及血清TNF-α含量的影响

Effects of Ginsenosides on CD4^+/CD8^+ T cell ratio and concentration of TNF-α in immunosuppressive mice

为探讨人参皂苷的免疫促进作用,本试验将50只昆系小鼠随机平均分为5组:空白对照组,免疫抑制模型组及免疫抑制小鼠人参皂苷高(0.1 mL/d)、中(0.5 mL/d)、低(1 mL/d)剂量组,免疫抑制小鼠用环磷酰胺腹腔注射(75mg/kg.BW)造模,分别检测小鼠的外周血T细胞亚群(CD4+/CD8+)和血清TNF-α含量的变化情况。结果表明,人参皂苷对免疫抑制小鼠外周血CD4+/CD8+T淋巴细胞亚群的比例以及小鼠血清TNF-α的含量均有一定的促进和提高作用。

In order to investigate the immunological enhancement function of Ginsenosides（GS）,50 Kunming mice were randomly divided into 5 groups,blank control group,immunosuppressive group and three dose groups of GS（0.1,0.5 mL/d） in immunosuppressive mice.The immunosuppressive mice model were established by intraperitoneal injection of cyclophosphamide（CY） 75 mg/kg·BW.The index of CD4＋/CD8＋ T cell ratio and the concentration of TNF-α in serum of each group were observed.The results were as follows：GS had certain promotion and enhancement to the CD4＋/CD8＋ T cell ratio in peripheral blood of the immunosuppressive mice as well as the mice＇s blood serum TNF-α content.