转移抑制基因nm23/NDPK与肺癌生物学行为的相关性研究

The correlative study of metastasis suppressor gene nm23/NDPK in human lung carcinoma

目的：研究转移抑制基因ｎｍ２３ 表达产物二磷酸核苷激酶（ＮＤＰＫ）在人肺癌中的表达及意义。方法：应用免疫组化ＳＰ法，检测不同病理分级及淋巴结有无转移肺癌组织中ｎｍ２３／ＮＤＰＫ 的表达。结果：８８ 例肺癌ｎｍ２３／ＮＤＰＫ 阳性表达率为８１－８２％ （７２／８８），其中呈高表达率３６－３６ ％（３２／８８） 。高分化肺癌高表达率７１－４３％ （１０／１４），中分化肺癌高表达率４１－３ ％（１９／４６） ，低分化肺癌高表达率１０－７２ ％ （３／２８） 。各组间有显著差异（ Ｐ＜ ０－０５）。而与肺癌有无肺门淋巴结转移无关（ Ｐ＞ ０－０５）。结论：ｎｍ２３／ＮＤＰＫ 的表达与肺癌的分化程度呈负相关，可作为预测肿瘤转移潜能及预后的指标之一。

Purpose To study expression and significance of the metastasis suppressor gene nm23/NDPK in human lung carcinoma. Methods The expression of nm23 in 88 cases of lung cancer was deteted using immunohistochemical S P method. Results 81 82%(72/88) showed positive staining, and strong positive staining was 36 36% (32/88). The positivity rates in high, middle and low differentiation lung cancer were 71 43%(10/14), 41 3%(19/46) and 10 72%(3/28). There was a significant difference among different groups in nm23 expression ( P <0 05), but nm23 expression wasnt correlated with lymph node metastasis ( P >0 05). Conclusion The nm23/NDPK expression levels are inversely correlated with the dexgree of differentiation in lung carcinoma and it may be as a index to forecast potential of the tumor metastasis and prognosis.