不同营养状态COPD肿瘤坏死因子-α测定及其临床意义

Clinical significance of detecting TNF-α in patients with chronic obstructive pulmonary disease of varying nutritional status

目的 研究肿瘤坏死因子－ α（ＴＮＦ－ α） 对慢性阻塞性肺疾病（ＣＯＰＤ） 营养状态的影响。方法 用放免法检测３５ 例不同营养状态的ＣＯＰＤ 患者急性加重期和稳定期血清ＴＮＦ－ α水平。结果 营养正常组（Ａ组） 急性加重期和稳定期ＴＮＦ－ α明显低于中度营养不良组（Ｂ组） 和重度营养不良组（Ｃ 组）（ Ｐ ＜ ０－０５， Ｐ ＜ ０－０１）；Ａ、Ｂ组急性加重期明显高于稳定期（ Ｐ＜０－０５），而Ｃ组无显著性变化（ Ｐ＞０－０５）。结论 ＣＯＰＤ患者的营养状态与血清ＴＮＦ－ α水平有一定关系，ＴＮＦ－α增高可能导致ＣＯＰＤ患者病情加重和营养状态恶化。

Objective To study the effects of tumor necrosis factor-α(TNF-α) on nutritional status of chronic obstructive pulmonary disease(COPD).Methods TNF-α was detected in 35 COPD of varying nutritional condition in acute exacerbation and convalescent phase by radioimmunoassay.Results The levels of TNF-α in normonourished group (A group) were lower than moderate undernourished (B group) and severe undernourished (C group)(P<0 05,P<0 01) in acute exacerbation and convalescent phase,and A,B group statistically increased in acute exacerbation(P<0 05),but C group was without significant change(P>0 05).Conclusion The levels of TNF-α may have an influence on nutritional status of COPD.The disease and nutritional condition may deteriorate in COPD with higher levels of TNF-α.