甲钴胺联合前列地尔治疗糖尿病周围神经病变的疗效观察

Effects of Combination of Mecobalamin and Alprostadil on Diabetic Peripheral Neuropathy

目的:观察比较甲钴胺联合前列地尔,单用甲钴胺及单用维生素B12治疗糖尿病周围神经病变的疗效。方法:将60例糖尿病周围神经病变患者随机分为3组,治疗组1(20例)给予甲钴胺0.5mg肌内注射,每天1次,同时给予前列地尔10μg+0.9%氯化钠液10mL静脉推注,每天1次,连续2周;治疗组2(20例)给予甲钴胺0.5mg肌内注射,每天1次,连续2周;对照组(20例)用维生素B120.5mg肌内注射,每天1次,连续2周。每组均辅以丹参针剂静脉滴注治疗。结果:治疗组1、治疗组2患者症状和体征、各项神经传导速度与对照组相比均显著改善,而治疗组1与治疗组2之间临床疗效差异有统计学意义,且各组均无明显不良反应。结论:甲钴胺联合前列地尔治疗糖尿病周围神经病变疗效更好。

Objective：To observe the effects of combination of mecobalamin and alprostadil（PGE1）,mecobalamin only and vitamin 12 only on the patients with diabetic peripheral neuropathy（DPN）.Methods：A total of 60 patients with DPN were divided into three groups（Group1,Group 2,and control group）.Twenty patients in group1 were given mecobalamin（0.5 mg IM.qd.） and alprostadil（10 μg IV.qd.） for consecutive 2 weeks.Twenty patients in Group2 were only given mecobalamin（0.5 mg IM.qd.） for consecutive 2 weeks.Twenty patients in control group were only given vitamin（0.5 mg IM.qd.） for consecutive 2 weeks.All patients were received adjuvant therapy with salvia injection.Results：Compared with control group,complains and physical signs of patients and every nerve conduction velocity（NCV） improved.The effects of Group1 were better than that of Group2.No side effect was found in three groups.Conclusions：The combination of mecobalamin and alprostadil could obtain better effects in patients with DPN.