期刊文献+

卵巢上皮性癌免疫治疗研究现状 被引量:2

Research of Immunotherapy in Epithelial Ovarian Cancer
下载PDF
导出
摘要 在女性生殖道肿瘤中,卵巢癌患病率位居第3位,且病死率最高。即使行理想的肿瘤减灭术以及规范的化疗方案,晚期卵巢癌患者生存率仍然很低。因此,寻找有效的卵巢癌治疗方法是许多学者的研究目标。包括卵巢癌在内的许多种恶性肿瘤、均已被证明具有免疫原性。一些抗肿瘤因子与癌症有关联的最有力证据是通过对卵巢癌的研究被发现的。近20多年来进行了许多有关卵巢癌免疫治疗的临床试验,但结论却不尽明确。
作者 赵辉 孔为民
出处 《中国临床医学》 2011年第3期412-414,共3页 Chinese Journal of Clinical Medicine
  • 相关文献

参考文献16

  • 1Chu CS, Kim SH, June CH, et al. Immunotherapy opportu- nities in ovarian cancer[J]. Expert Rev Anticancer Ther, 2008, 8(2) :243-257.
  • 2Sato E, Olson SH, Ahn J, et al. Intraepithelial CD8^+ tumor- infiltrating lymphocytes and a high CD8^+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer [J]. ProcNatlAcadSciUSA, 2005, 102(51) :18538-18543.
  • 3Tomsova M, Melichar B, Sedlakova I, et al. Prognostic sig nificance of CD3 + tumor-infiltrating lymphocytes in ovarian carcinoma[J]. Gynecol Oncol, 2008, 108 (2) : 415-420.
  • 4Nemunaitis J, Sterman D, Jablons D, et al. Granulocyte-macrophage colony-stimulating factor gene-modified autolo- gous tumor vaccines in non-small-cell lung cancer[J]. J Natl Cancer Inst, 2004, 96(4) :326-331.
  • 5Wang B, Kaumaya PT, Cohn DE,et al. Immunization with synthetic VEGF peptides in ovarian cancer[J]. Gynecol On- col, 2010, 119(3) :564-570.
  • 6Die{enbach CS, Gnjatic S, Sabbatini P, et al. Safety and im- munogenicity study of NY ESO-lh peptide and montanide ISA-51 vaccination of patients with epithelial ovarian cancer in high-risk first remission[J]. Clin Cancer Res, 2008, 14 (9) :2740-2748.
  • 7Speetjens FM, Kuppen PJ, Welters MJ, et al. In duct ion of pB3-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal caneer[J]. Clin Cancer Res, 2009, 15(3) ; 1086-1095.
  • 8Dhodapkar MV, Dhodapkar KM, Palucka AK. Interactions of tumor cells with dendritic cells: balancing immunity and tolerance[J]. Cell Death Differ, 2008, 15(1):39-50.
  • 9Cao DY, Yang JY, Dou KF, et al. Alpha fetoprotein and in- terleukin-18 gene-modified dendritic cells effectively stimulate specific type-1 CD4- and CD8 mediated T Cell response from hepatocellular carcinoma patients in Vitro[J]. Hum Immu- nol, 2007, 68(5):334-341.
  • 10Peethamharam PP, Melisko ME, Rinn KJ, et al. A phase I trial of immunotherapy with lapuleucel-T (APC8024) in pa- tients with refractory metastatic tumors that express HER-2/ neu[J]. Clin Cancer Res, 2009, 15(8):5937-5944.

二级参考文献2

同被引文献38

  • 1厉倩,曹雪涛(审校者).树突状细胞与免疫负向调控[J].国际免疫学杂志,2006,29(1):48-51. 被引量:9
  • 2Petignat P. Ovarian cancer from therapy: study results from University Hospital in the area of ovarian cancer therapy published [ J ]. Clin Trails Week, 2007, 11 (2) : 66 - 68.
  • 3Naik SH. Demystifying the development of dendritic cell subtypes, a little [ J ]. Immunol Cell Biol, 2008, 86 ( 5 ) : 439 - 452.
  • 4Shurin GV, Ma Y, Shurin MR. Immunosuppressive mechanisms of regulatory dendritic cells in cancer [ J ]. Cancer Microenviron, 2013, 6(2) : 159 - 167.
  • 5Simonetti O, Goteri G, Iamarini G, et al. In melanoma changes of Immature and mature dendritic cell expression correlate with tumor thickness: an immunohistochendcal study [J]. Int J Irnnmnopathol Pharmacol, 2007, 20(2): 325-333.
  • 6Kantoff PW, Higano CS, Shore ND, et al. Sipuleueel-T immuno- therapy for castration-resistant prostate cancer [J]. N Engl J Med, 2010, 363(5) : 411 -422.
  • 7Liu B, Nash J, Runowicz C, et al. Ovarian cancer immuno-therapy: opportunities, progresses and challenges [ J ]. J Hematol Oncol, 2010, 3: 7.
  • 8Hung CF, Wu TC, Monie A, et al. Antigen-specific immunotherapy of cervical and ovarian cancer[J]. Immunol Rev, 2008, 222:43 -69.
  • 9Sabado RL, Bhardwaj N. Directing dendritic cell immunotherapy towards successful cancer treatment [ J ]. Immunotherapy, 2010, 2 (1): 37 -56.
  • 10Gnjatie S, Nishikawa H, Jungbluth AA, et al. NY-ESO-1 : review of an immunogenic tumor antigen [ J ]. Adv Cancer Res, 2006, 95 : 1 -30.

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部