卵巢上皮性癌中P-选择素的表达及临床意义

Expression and clinical significance of P-selection in epithelial ovarian carcinoma tissues

目的探讨研究P-选择素在正常卵巢组织、卵巢良性肿瘤组织、卵巢交界性上皮性肿瘤及卵巢上皮性癌中的表达及与卵巢上皮性癌临床病理特征的关系。方法随机选取吉林大学中日联谊医院和长春市中心医院2008年1月-2009年10月间手术切除的组织标本,其中正常卵巢组织20例、卵巢良性上皮性肿瘤组织20例、卵巢交界性上皮性肿瘤18例和卵巢上皮性癌组织60例。应用免疫组织化学法对组织进行染色,以检测P-选择素的表达情况。结果 (1)P-选择素在不同性质的卵巢组织的细胞膜或细胞浆中均有表达,主要表达于细胞膜中,正常卵巢组织、良性上皮性肿瘤、交界性上皮性肿瘤、上皮性癌中的阳性表达率依次为10.0%、20.0%、27.8%、63.3%,整体之间的阳性表达率比较,差异有显著性。(2)P-选择素在卵巢上皮性癌中的表达随着手术-病理分期和组织病理学分级的升高而增加,而与肿瘤组织学类型无关。结论 (1)P-选择素可能参与卵巢上皮性癌的发生发展,在卵巢恶性肿瘤的发展中起着重要的作用;(2)P-选择素高表达促进了肿瘤的侵袭和转移,表达越高,恶性程度越高、预后越差、越易复发。

Objective To study the expression of P-selection in normal ovarian tissue,benign ovarian tumor,borderline epithelial ovarian tumor and epithelial ovarian carcinoma and its relationship to clinical and pathological features of epithelial ovarian carcinoma.Methods Randomly selecting surgical resection specimens in the China-Japan Union Hopsital of Jilin University and Central Hospital of Changchun between January 2008-October 2009,including 20 cases of normal ovarian tissue,20 cases of benign ovarian epithelial tumors 18 cases of borderline epithelial ovarian tumor and 60 cases of o epithelial ovarian carcinoma,using immunohistochemical method to stain tissues to detect the expression of P-selection.Results（1）P-selectin was all expressed in the membrane and cytoplasm in different types of ovarian tissue,and mainly expressed in the membrane,the positive expression rates of P-selectin were 10.0%,20.0%,27.8%,63.3% respecttively,according to the order of normal ovarian tissues,benign epithelial ovarian tumor,borderline epithelial ovarian tumor and epithelial ovarian carcinomas,the differences between the overall were statistically significant.（2）The positive expression rates of P-selectin in epithelial ovarian cancer increased,as surgical-pathologic staging progressed and histopathologic grade got higher,had no relationship with histological type.Conclusion（1）P-selectin may be involved in the occurrence and development of epithelial ovarian cancer,and plays an important role In the development of epithelial ovarian cancer.（2）The high P-selectin expression may promote the invasion and metastasis proeess of epithelial ovarian cancer,higher P-selectin expression,the higher the degree of malignancy,the worse the prognosis,the more easy to relapse.