期刊文献+

莱姆病螺旋体的转移感染和致病机制 被引量:3

Mechanism of infection transmission and pathogenesis of Borrelia burgdorferi
原文传递
导出
摘要 本文主要就莱姆病螺旋体从蜱到宿主动物的转移感染以及在宿主体内存活并致病的机制进行了的阐述,包括螺旋体在蜱内定居以及感染宿主动物过程中蛋白的变化及作用;螺旋体在宿主体内致病的各种机制(病原体本身的作用、免疫逃避、细胞因子的作用、自身免疫)。 The paper describes the mechanism of transmission of Borrelia burgdorferi from ticks to host animals and pathogenesis in host animals,including the colonizing of B.burgdorferi in ticks,the change and role of its proteins in infecting host animals and all the pathogenic mechanisms of B.burgdorferi in host animals(self role of pathogen,immune evasion,function of cytokines and autoimmunity).
出处 《疾病监测》 CAS 2011年第6期475-478,共4页 Disease Surveillance
基金 国家科技重大专项(艾滋病和病毒性肝炎等重大传染病防治专项)课题(No.2008ZX10004-010 No.2009ZX10004-203)~~
关键词 莱姆病螺旋体 转移 致病 机制 Borrelia burgdorferi transmission pathogenesis mechanism
  • 相关文献

参考文献28

  • 1耿震,万康林.莱姆病流行病学研究新进展[J].中国自然医学杂志,2007,9(2):158-160. 被引量:32
  • 2宝福凯,Erol Fikrig.伯氏疏螺旋体传播过程中病原体、媒介、宿主间的相互作用(英文)[J].中国媒介生物学及控制杂志,2008,19(3):264-268. 被引量:9
  • 3Pal U, Li X, Wang T, et al. TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi[ J]. Cell,2004,119:457 - 468.
  • 4Grimm D, Tilly K, Byram R, et al. Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals[J]. Proc Natl Acad sci USA ,2004, 101 : 3142 -3147.
  • 5Ramamoorthi N, Narasimhan S, Pal U, et al. The lyme disease agent exploits a tick protein to infect the mammalian host [ J ]. Nature, 2005,436:573 - 577.
  • 6TillyK, Bestor A, Jewett MW, et al. Rapid clearance of lyme disease spirochetes lacking OspC from skin [J]. Infect Immun, 2007,75(3) :1517 - 1519.
  • 7Daix V, Schroeder H, Praet N, et al. Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins[J]. Insect Mol Biol,2007,16(2) : 155 - 166.
  • 8Fraser CM, Casjens S, Huang WM, et al. Genomic sequence of a lyme disease spirochaete, Borrelia burgdorferi [ J ]. Nature, 1997,390 ( 6660 ) :580 - 586.
  • 9Labandeira-Rey M, Skare JT. Decreased infectivity in Borrelia burgdorfri strain B31 is associated with loss of linear plasmid 25 or 28 - l [J]. Infect Immun,2001,69( 1 ) :446 -455.
  • 10Jewett MW, Lawrence K, Bestor AC, et al. The critical role of the linear plasmid Ip36 in the infectious cycle of Borrelia burgdorferi[ J]. Mol Microbiology,2007,64 ( 5 ) : 1358 - 1374.

二级参考文献116

共引文献48

同被引文献34

引证文献3

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部