期刊文献+

子痫前期患者血清对氧磷酶活力检测及其意义

原文传递
导出
摘要 目的研究对氧磷酶1(PON1)活力和血脂脂蛋白水平在子痫前期(PE)发病中的相关性。方法应用全自动生化分析仪测定血脂脂蛋白,乙酸苯酯法测定PON1活力。结果①重度子痫前期组胆固醇(CHOL)、甘油三脂(TG)、低密度脂蛋白(LDL)和载脂蛋白B(apoB)均比健康孕妇组高,而高密度脂蛋白(HDL)和载脂蛋白A(apoA)比健康孕妇组低。轻度子痫前期组TG、HDL、apoA和apoB与健康孕妇组差异显著,CHOL和LDL与健康孕妇组类似,与重度子痫前期组差异显著。②子痫前期组PON1活力低于健康孕妇组,子痫前期组中轻度和重度类似。③PON1活力与apoA、HDL和LDL间存在关相性,相关系数分别为0.33、0.33和-0.24。结论 PON1活力与血脂脂蛋白代谢紊乱相关,其下降可能在子痫前期发病中起着重要作用。
出处 《海峡预防医学杂志》 CAS 2011年第3期82-84,共3页 Strait Journal of Preventive Medicine
  • 相关文献

参考文献8

  • 1Akhavan S, Modarres G, Borna S. Maternal plasma lipid concen- trations in first trimester of pregnancy and risk of sever pre- eclapmsia[J]. Pak J Med Sci,2009,25(4) :563-567.
  • 2Sapian-Raezkowska B, Rabezyflski M, Adamiee R. Paraoxonase-- important enzyme of the lipid metabolism and potential ally in the antiatheroselerotic treatment[J]. Pol Merkur Lekarski, 2010,29 (173) : 325-327.
  • 3Gonzdlez AI,Brites F,Elbert A, et al. Relation between paraoxo- nase activity, other HDL components and inflammatory state in hemodialyzed patients[J]. Medicina (B Aires), 2010,70 (6) : 508- 512.
  • 4Camps J,Marsillach J, Rull A, et al. Interrelationships between paraoxonase-1 and monocyte chemoattraetant protein-1 in the regulation of hepatic inflammation[J]. Adv ExpMed Biol,2010, 660:5-18.
  • 5Rozenberg. Paraoxonase(PON1)deficiency is associated with in- creased macrophage oxidative stress: studies in PONl-knockout mice[J]. Free Radic Biol Med, 2003,34 (6) : 774-784.
  • 6Kumrua S,Aydin S, Ferit GM, et al. Changes of serum paraoxo- nase(an HDL-cholesterol-associated [ipophilic antioxidant) and arylesterase activities in severe preeclamptic women[J]. Europ J Obstet Gynecoand Reprod Biol,2004,114(2):177-181.
  • 7李季滨,孙娅,牛凤霞,齐向红.子痫前期患者对氧磷酶活性及循环内皮细胞变化的临床意义[J].山东医药,2009,49(37):78-79. 被引量:1
  • 8Otoeka A,Oowska M. The role of genetic(PON1 polymorphism) and environmental factors, especially physical activity, in antioxi-dant function of paraoxonase[J]. Postepy Hig Med Dosw, 2009, 30(63) :668-677.

二级参考文献5

  • 1许瑞环,李常玲,郑锐青,尹学念,孙鹏.妊娠高血压综合征患者血清对内皮细胞表达CD226的影响[J].细胞与分子免疫学杂志,2004,20(4):470-472. 被引量:4
  • 2戚国庆,贾彬,杜文涛,杨备战,夏岳,李永星,李博,魏立业.冠心病患者血清对氧磷酶1活性对氧化低密度脂蛋白水平的影响[J].临床荟萃,2006,21(24):1783-1784. 被引量:11
  • 3Laskowska M, Vinson GP, Szumilo J, et al. Comparative analysis of the angiotensin-Ⅱ recepter in placental vascular endothelial cells in preeclamptic and normotensive patients[ J]. Gynecol Obstet Invest, 2003,56( 1 ) :55-60.
  • 4Solovey A, Gui L, Ramakrishnan S, et al. Sickle cell anemia as a possible state of enhanced anti-apoptotic tone: survival effect of vascular endothelial growth factor on circulating and unanehorcd endothelial cells[J]. Blood, 1999,93(Ⅱ) : 3824-3830.
  • 5Rozenberg O, Rosenblat M, Coleman R, et al. Paraoxonase ( PON1 ) deficiency is associated with increased macrophage oxi-datire stress: studies in PON1-knockout mice[J]. Free Radic Biol Med, 2003,34(6) :774-784.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部