口服补锌辅助治疗婴幼儿迁延性慢性腹泻病70例

Clinical Effect of Adjuvant Treatment of Oral Zinc Supplementation in Infants With Persistent or Chronic Diarrhea

目的探讨迁延性慢性腹泻病患儿的血锌水平,并观察口服补锌治疗婴幼儿迁延性慢性腹泻病的临床疗效及意义。方法对130例迁延性慢性腹泻病患儿进行血锌检测,并与正常儿童进行对照。将130例患儿随机分成治疗组(70例)和对照组(60例)。两组均给予常规治疗,治疗组加予口服补锌(赖氨葡锌颗粒)治疗,并观察其疗效。结果迁延性慢性腹泻病患儿的血锌值低于正常儿童,补锌治疗组总有效率(91.4%),明显高于对照组(73.3%),平均腹泻停止时间及平均住院天数也较对照组明显缩短,两组比较差异均有显著性(P<0.05)。结论迁延性慢性腹泻病存在缺锌现象,补锌辅助治疗小儿迁延性慢性腹泻病有一定疗效。

Objective To investigate the level of blood zinc and to observe the clinical effect of adjuvant treatment of oral zinc supplementation in infants with persistent or chronic diarrhea. Methods 130 cases of infants with persistent or chronic diarrhea were detected for the level of blood zinc, and compared with normal children. The 130 cases were randomly divided into the treatment group （70 cases） and the control group （60 cases）. Both groups were given routine thera- py, additionally the treatment group were given adjuvant treatment of oral zinc supplementation, and the clinical effect of all the cases were observed. Results The level of blood zinc in infants with persistent or chronic diarrhea were lower than that of normal children,the total clinic effective rate of the treatment group was 91.4% ,significantly higher than that of the control group, which total clinic effective rate was 73.3%. The average time to stop diarrhea and the total treatment time were significantly shorter than that of the control group（ P 〈 0.05 ）. Conclusions The blood zinc deficiency phenomenon was existed in infants with persistent or chronic diarrhea; and the zinc adjuvant therapy in the persistent and chronic diarrhea in infants was useful. It can shorten the time to stop diarrhea, get the higher total effective rate, and be easy to do.