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ING4基因与肿瘤研究新进展 被引量：1

Advancement of study between ING4 gene and tumor
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摘要 ING4基因是肿瘤抑制因子家族的新成员,近来研究发现,ING基因在正常组织中表达丰富,但在多种恶性肿瘤组织,如乳腺癌、胶质瘤、肺癌等中表达明显下调,ING4可通过增强p53基因的活性、恢复细胞间接触抑制、抑制肿瘤血管生成、抑制HIF的活性而抑制肿瘤的生长,还能诱导细胞凋亡,增加肿瘤细胞对放化疗的敏感性,本研究对ING4基因与肿瘤研究的新进展进行综述。 ING4 is considered to be a novel candidate tumor suppressor gene.Recently,it has been reported that ING4 was significantly downregulated in several malignancies such as breast tumor,glioma,lung cancer and so on.ING4 is involved in tumor growth inhibition through enhancement of p53 activity,suppression of loss of contact inhibition,angiogenesis repression,inhibition of HIF activity.In addition,ING4 can induce apoptosis enhancement and chemo-radio-sensitization of tumor cells.In this article,our purpose is to review the recent progress of study on ING4 in human tumors.
作者 潘旋 王朝霞
机构地区 南京医科大学第二附属医院肿瘤科
出处 《中国医药科学》 2011年第13期42-44,共3页 China Medicine And Pharmacy
基金 江苏省自然科学基金资助项目(编号:BK2010590)
关键词 ING4基因 抑癌机制 肿瘤 ING4 Tumor suppressor Tumor
分类号 R730.5 [医药卫生—肿瘤]
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参考文献30

  • 1曹芳,魏钦俊,鲁雅洁,潘梅,曹新.ING4基因表达对乳腺癌细胞生长抑制作用的研究[J].肿瘤,2008,28(4):301-304. 被引量：5
  • 2田玥.腺病毒介导的hING4基因联合持续低剂量率γ射线照射治疗胰腺癌的体外实验研究[D]苏州大学,苏州大学2008.
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二级参考文献11

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中国医药科学
2011年 第13期

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