硫酸镁联合拉贝洛尔治疗重度妊娠高血压综合征临床疗效观察

Clinical observation of labetalol and magnesium sulfate treatment of pregnancy-induced hypertension

目的探讨硫酸镁联合拉贝洛尔治疗重度妊娠高血压综合征(PIH)的临床疗效。方法选择笔者所在医院2009年1月～2011年2月收治的重度PIH孕妇86例,随机分为对照组和治疗组各43例,对照组给予硫酸镁常规解痉降压,观察组则在硫酸镁基础上,应用拉贝洛尔针加入5%葡萄糖注射液中静脉点滴。结果两组患者治疗后血压控制有效率观察组明显优于对照组,差异有统计学意义(P<0.05);并发症发生率上,两组患者在宫颈裂伤、子宫过度刺激、产后出血的发生率均有显著性差异(P<0.05)。结论硫酸镁联合拉贝洛尔治疗重度PIH效果确切,能有效降低患者平均动脉血压,改善母婴结局,具有广阔的临床应用前景。

Objective To investigate the clinical efficacy of treatment of magnesium sulfate and labetalol for pregnancy induced hypertension.Methods 86 cases in January 2009 to February 2011 PIH pregnant women were treated and were randomLy divided into control and treatment group,43 cases of control group was given magnesium sulfate buck conventional spasm was observed in the magnesium sulfate group based on the application needle labetalol in 5% glucose intravenous injection.Results There were efficient control of blood pressure after treatment observation group than the control group,the difference was statistically significant（P 0.05）;complication rate,the two groups in cervical laceration,uterine hyperstimulation,postpartum incidence of bleeding was significantly different（P 0.05）.Conclusion Magnesium sulfate treatment of PIH combined effect of labetalol exactly can effectively reduce the mean arterial blood pressure of patients,improve maternal and child outcomes,with a broad clinical application.