T-幼淋细胞白血病1例并文献复习

T-cell prolymphocytic leukemia in one case and the literature review

目的:分析总结T-幼淋细胞白血病的临床特点、诊断及治疗现状。方法:回顾性分析1例T-幼淋细胞白血病患者临床资料并复习相关文献。结果:骨髓穿刺可见幼淋细胞,流式细胞学分析示CD2+CD3+CD5+CD7+CD8+CD4-TdT-HLA-DR-CD1a-CD19-。染色体:46,XX,inv(14)(q11;q32)。给予化疗,化疗第10天突发低血容量性休克自动出院。结论:T-幼淋细胞白血病是一种少见的胸腺后淋巴细胞增殖性疾病,侵袭性高,中位生存期短。多种新药的临床应用及异基因干细胞移植为该病提供了治疗前景。

Objective To analyze and summarize the clinical characteristics,the diagnosis and the therapy of T-cell prolymphocytic leukemia.Methods The clinical data of one patient with T-cell prolymphocytic leukemia were investigated retrospectively and the relevant literature was reviewed.Results The bone marrow picture showed prolymphocytic T-cell.Flow cytometry showed that these abnormal cells expressed CD2＋ CD3＋CD5＋CD7＋CD8＋CD4-TdT-HLA-DR-CD1a-CD19-.Chromosome analysis had the following karyotype： 46,XX,inv（14）（q11;q32）.This patient received CHOP therapy and achieved therapeutic effect.The patient left the hospital due to hypovolemic shock on the tenth day.Conclusion T-cell prolymphocytic leukemia is a rare lymphoproliferative disease,with high invasive ability and short median survival time.Some new drugs and allogeneic hemotoic stem cell transplantation supply more therapeutic selection.