纳米技术在中枢神经系统中的作用

Application of nanotechnology in the central nervous system

纳米技术是指在0.1-100nm量度范围内对物质结构和制造技术进行研究。纳米粒子能够进入细胞并与细胞及其组织发生作用,从而在分子水平上产生生物效应。由于纳米粒子可以和有机高分子多肽、无机盐等结合通过血脑屏障,已经在中枢神经系统药物转运、中枢神经系统疾病的诊断和治疗中发挥重要作用。本文从纳米粒子与血脑屏障的关系、纳米粒子在神经系统的保护、神经系统的再生中的作用等几方面阐述纳米技术在中枢神经系统应用中的现状与前景。

Nanotechnology refers to study of the structure of material and manufacturing technology,ranging from a few to about 100 nanometers.Nanoparticles can enter cells and interact with cells and their tissues,resulting in biological effects at the molecular level.As nanoparticles can combine with organic high polymer polypeptides,inorganic salt etc,and then across the blood-brain barrier（BBB）,it has played the important role in the central nervous system （CNS） drug delivery,CNS diseases diagnosis and therapy.In this review,we would elaborate the research status and prospects of nanotechnology in CNS application from several aspects including the relationship between nanoparticles and BBB,the role of nanoparticles in the neuroprotection and neuroregeneration.