药物基因组学研究对急性冠脉综合征个体化治疗的启示
被引量:2
摘要
急性冠脉综合征是由冠状动脉痉挛引起动脉粥样斑块不稳定、破裂、血栓形成,可引发不稳定心绞痛、心肌梗死或猝死。许多心血管病药物,如抗血小板药物、抗凝药、他汀类、13受体阻滞剂等,有效治疗剂量存在较大的个体差异。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2011年第24期1722-1724,共3页
National Medical Journal of China
基金
国家自然科学基金(81070172)
国家重点基础研究发展规划“973”项目(2011CB503901)
参考文献29
-
1Evans WE, MeLeod HL. Pharmaeogenomics-drug disposition, drug targets, and side effects. N Engl J Med,2003 ,348 :538-549.
-
2Goodman T, Ferro A, Shanna P. Pharmacogenetics of aspirin resistance: a comprehensive systematic review. Br J Clin Pharmacol, 2008,66 .. 222 -232.
-
3Shuldiner AR, O' Connell JR, Bliden KP, et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA, 2009,302 : 849- 857.
-
4Mega JL, Close SL, Wiviott SD, et al. Cytochrome p--450 polymorphisms and response to clopidogrel. N Engl J Med,2009, 360:354-362.
-
5Collet JP, Hulot JS, Pena A, et al. Cytoehrome P450 2C19 polymorphism in young patients treated with elopidogrel after myocardial infarction: a cohort study. Lancet, 2009,373: 309- 317.
-
6Mega JL, Close SL, Wiviott SD, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 triM: a pharmaeogenetic analysis. Lancet,2010,376:1312-1319.
-
7Xie HG, Kim RB, Wood AJ, et al. Molecular basis of ethnic differences in drug disposition and response. Annu Rev Pharmacol Toxico1,2001,41 : 815-850.
-
8Chen BL, Zhang W, Li Q, et al. Inhibition of ADP-indueed platelet aggregation by clopidogrel is related to CYP2C19 genetic polymorphisms. Clin Exp Pharmacol Physiol,2008,35: 904-908.
-
9Mega JL, Close SL, Wiviott SD, et al. Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation ,2009,119 : 2553-2560.
-
10Beitelshees AL, Horenstein RB, Vesely MR, et al. Pharmacogenetics and clopidogrel response in patients undergoing percutaneous coronary interventions. Clin Pharmacol Ther, 2011, 89 : 455-459.
同被引文献16
-
1Aukrust P,Sandberg WJ,Otterdal K,et al .Tumor necrosis factorsuperfamily molecules in acute coronary syndromes[J].Annalsof Medicine,2011,43(2):90 -103.
-
2Hohensinner PJ,Niessner A,Huber K,et al . Inflammation andcardiac outcome [J]. Current Opinion in Infectious Diseases,2011,24(3):259 -264.
-
3Wolk R,Bertolet M,Brooks MM,et al .Differential effects of insu- lin sensitization and insulin provision treatment strategies onconcentrations of circulating adipokines in patients with diabetesand coronary artery disease in the BARI 2D trial[J].EuropeanJournal of Preventive Cardiology,2016,23(1):50-58.
-
4Narverud I,Ueland T,Nenseter MS,et al .Children with familialhypercholesterolemia are characterized by an inflammatory im- balance between the tumor necrosis factor system and interleu- kin 10[J].Atherosclerosis,2011,214(1):163-168.
-
5Libby P,Tabas I,Fredman G,et al .Inflammation and its resolu- tion as determinants of acute coronary syndromes[J].CirculationResearch,2014,114(12):1867-1879.
-
6Swardfager W,Herrmann N,Cornish S,et al .Exercise interven- tion and inflammatory markers in coronary artery disease:a metaanalysis[J].American Heart Journal,2012,163(4):666- 676.
-
7Dowlati Y,Herrmann N,Swardfager W,et al .A meta analysisof cytokines in major depression[J].Biological Psychiatry,2010,67(5):446- 457.
-
8Colombo PC,Ganda A,Lin J,et al .Inflammatory activation:car- diac,renal,and cardio renal interactions in patients with thecardiorenal syndrome[J].Heart Failure Reviews,2012,17(2):177- 190.
-
9Steptoe A,Molloy G J,Messerli Bürgy N,et al .Fear of dyingand inflammation following acute coronary syndrome[J].Europe- an Heart Journal,2011,32(19):2405 -2411.
-
10朱海霞.慢性心力衰竭患者血清白介素6、高敏C反应蛋白和肿瘤坏死因子α水平的变化及临床意义[J].中国全科医学,2011,14(29):3362-3363. 被引量:53
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-
1蒋延春,周白丽.炎性介质在急性冠脉综合征中的研究进展[J].青海医药杂志,2022,52(12):60-63.
-
2景霞,鹿育萨.肺炎支原体感染与社区获得性肺炎合并急性心肌梗死的关系[J].中西医结合心脑血管病杂志,2018,16(2):208-210. 被引量:4
-
3胡伟,王国兵,胡孝彬,刘翔.急性心肌梗死患者外周血TLR4、血清TNF-α水平变化及临床意义[J].中国医药导报,2019,16(1):153-156. 被引量:9
-
4叶伍飞,刘俊,赖伟华,马培志,封卫毅,栾家杰.阿哌沙班集中带量采购中选仿制药与原研药的临床疗效和安全性研究[J].中国医院用药评价与分析,2024,24(8):919-922.
-
1蒋和平,叶思潮,黄清梅.心血管病药物停药综合征[J].现代诊断与治疗,1995,6(6):378-379.
-
2陈志春.心血管病药物服用时间有讲究[J].开心(老年),2009,0(6):55-55.
-
3心血管疾病药物治疗高峰论坛2016启事[J].中华心血管病杂志,2016,44(3):249-249.
-
4王敏臣,杨晓清.β-受体阻滞剂在心血管疾病中的临床应用[J].内科,2013,8(4):412-414. 被引量:4
-
5甘露春.心脏不适未必是心脏病[J].养生保健指南,2013(4):61-61.
-
6周书婷,肖春月,王瑷珉,秦学东,王和平,张雪孪,曹银芳,郭瑞敏.通心络联合曲美他嗪对冠心病合并糖尿病患者血脂及心功能影响的临床研究[J].中国医药导报,2013,10(27):76-78. 被引量:12
-
7曲西宏,牛长斌.非ST段抬高型急性冠脉综合征90例临床治疗观察[J].中国临床实用医学,2010(2):126-127.
-
8郭静萱,刘健.急性ST段抬高型心肌梗死治疗的新视点[J].中国循环杂志,2008,23(1):1-2. 被引量:8
-
9王东海,黄彬森,姬东云.鲁南欣康联合通心络治疗冠心病心绞痛42例临床观察[J].云南中医中药杂志,2009,30(6):16-17. 被引量:12
-
10林智海,王正东,陈坚.左卡尼汀治疗不稳定型心绞痛的临床疗效观察[J].中国实用医药,2013,8(35):165-166.