局部碘-125放射性粒子植入治疗胰腺癌的疗效评价

The therapeutic evaluation of iodine-125 radioactive seeds implantation in pancreatic carcinoma

目的通过临床病例对比分析,探讨恶性肿瘤局部放射性粒子植入这一新兴治疗手段在治疗胰腺癌方面的优势及未来前景。方法收集在西安交通大学医学院第二附属医院初诊住院的胰腺癌患者104例,根据住院期间接受的主要治疗方式分为3组,比较3组患者治疗后症状缓解情况、住院时间以及治疗的副作用和并发症,同时随访其治疗后远期症状缓解情况、生活质量及生存期。结果 3组间出现胰瘘、消化道梗阻、骨髓抑制、平均初诊住院时间及平均生存期有显著差异,其余各项统计无明显差异。结论碘-125放射性粒子植入治疗胰腺癌在临床收益方面强于其他传统治疗方法,可作为中晚期胰腺癌治疗的有力补充。

Objective To discuss the advantages and application prospect of iodine-125 radioactive seeds implantation for pancreatic carcinoma by clinical comparison.Methods We collected 104 medical records of pancreatic carcinoma in the Second Affiliated Hospital,Medical School of Xi’an Jiaotong University.The 104 hospitalized cases were divided into 3 groups according to the main treatments received.The three groups were compared in symptomatic remission after treatment,hospitalization time,side effects and complications as well as follow-ups of their long-term symptom remission,life quality and life span.Results Pancreatic fistula,gastrointestinal obstruction,bone marrow suppression,overall length of hospital stay and average life span of the three groups were significantly different.However,the three groups did not differ significantly in other characteristics.Conclusion The performance of iodine-125 radioactive seeds implantation is more acceptable for pancreatic carcinoma than other traditional therapies.Therefore,it can be used as an effective treatment for patients with intermediate and advanced pancreatic carcinoma.