摘要
细胞的能量主要来自糖酵解和线粒体的有氧氧化.细胞活性和能量状态密切相关,恶性肿瘤由于其生长迅速,常常出现葡萄糖摄取量增高、糖酵解增加和乳酸堆积现象.通过介绍肿瘤能量代谢机制研究进展,结合代谢成像技术,将会有助于深入揭示肿瘤能量代谢改变与肿瘤进展的因果关联,为靶向能量代谢的肿瘤治疗策略提供新的视野和契机.
The cellular energy derives mainly from glycolysis and mitochondrlal OXlClatlon, ana celmtar activity correlates closely with energy status. Cancer cells have much higher rate of glucose uptake and increased glycolysis, produce high levels of lactate. Current advances in bioenergy metabolic mechanism of cancer were expounded. With intense investigation in this field combined development of metabolic imaging techniques, it will benefit unveiling the causal relationship between metabolic alteration and progress of cancer and be harnessed therapeutically.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2011年第7期585-592,共8页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目(90813028
30801387
30930101)~~
