摘要
简要总结DNA羟甲基化在小鼠胚胎干细胞(mouse embryonic stem cells,mESC)中的最新研究进展.DNA甲基化(DNAmethylation)影响染色质的结构与功能,在发育与疾病发生过程中具有重要作用.2009年Tahiliani等发现TET1可以催化甲基化胞嘧啶(5-methylcytosine,5mC)氧化为羟甲基化胞嘧啶(5-hydroxymethylcytosine,5hmC).DNA羟甲基化(DNAhydroxymethylation)被认为是调节DNA甲基化的一种重要方式,成为了表观遗传学的研究热点之一.
DNA methylation regulates chromatin structure and function, playing key roles during development and in diseases. Since Tahiliani et ol. identified TETI as the first hydroxylase of 5mC in 2009, DNA hydroxymethylation, an important regulating way for DNA methylation, has become the hotspot of epigenetics. Here, the recent research progress ofDNA hydroxymethylation in mouse embryonic stem cells was summarized.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2011年第7期611-614,共4页
Progress In Biochemistry and Biophysics
基金
国家重点基础研究发展计划(973)资助项目(2009CB825602
2009CB825603)~~
