胃癌组织B7-H3表达及其临床意义的探讨

Significance of expression of B7-H3 in human gastric carcinoma tissues

目的:研究B7-H3在胃癌组织中的表达及其与各临床病理变量之间的相关性。方法:采用免疫组织化学法检测113例胃癌手术标本中B7-H3蛋白的表达,分析其与肿瘤浸润性T淋巴细胞及各临床病理参数间的相关性。结果:B7-H3在胃癌组织中高表达(46.9%,53/113);B7-H3的表达与肿瘤浸润性T淋巴细胞呈负相关,P<0.05。淋巴结阳性组中B7-H3+群的百分比(54.8%,40/73)高于无淋巴结转移组(32.5%,13/40),P<0.05。Ⅰ、Ⅱ期患者标本中B7-H3的阳性表达率要明显低于Ⅲ+Ⅳ期组,P<0.05。结论:B7-H3在胃癌组织中高表达,与肿瘤分期、淋巴结转移正相关,与肿瘤浸润T淋巴细胞呈负相关。B7-H3可能通过抑制间质中T细胞的浸润介导胃癌肿瘤免疫逃逸。

OBJECTIVE：To study the expression of B7-H3 and its relation with cancer clinicopathological variables in gastric carcinoma tissues. METHODS：The expression of B7-H3 in 113 surgically resected specimens of gastric carcinoma was evaluated immunohistochemically. RESULTS： In these tumor specimens, 46.9%（53/113） of specimens was positive for B7-H3, which was observed in the cell membrane and/or cytoplasm. The number of T infiltrating lymphoid cells （TILs） in the tumor tissues was much lower in the B7 H3 positive cases than the negative cases（P〈0.05）. And it was found that B7-H3 expression was significantly more common in cases with lymph node metastasis [54.8%（40/73） vs 32.5% （13/40）） and stage Ⅲ＋Ⅳ（P〈0.05）. CONCLUSION：B7-H3 is expressed in the tissues of gastric carcinoma, and B7 H3 expression is negatively correlated with the number of TILs,which may represent one of the immune escape mechanisms for gastric carcinoma.