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大鼠肾间质纤维化中微小RNA-21的表达变化及其机制 被引量：4

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摘要 肾问质纤维化是许多肾脏疾病的重要病理变化，转化生长因子β（TGF-8）信号通路的活化是纤维化发生的重要标志，抑制TGF-β信号通路可以明显缓解肾问质纤维化[1]。
作者 徐丽娟 李照辉 卢晓昭 罗会文 邹晓荣 于桂芹
机构地区 解放军第 第四军医大学生物化学与分子生物学教研室
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2011年第7期536-537,共2页 Chinese Journal of Nephrology
关键词 肾间质纤维化 表达变化 转化生长因子Β 大鼠 信号通路 TGF-Β 病理变化 肾脏疾病
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献6

  • 1黄平,张月娟,黄渊,赵晶晶,蒋涛,张农.细胞外信号调节激酶信号通路与醛糖还原酶对转化生长因子β1诱导人系膜细胞纤连蛋白表达的影响[J].中华肾脏病杂志,2010,26(5):346-351. 被引量：4
  • 2Jiang X, Tsitsiou E, Herrick SE, et al. MieroRNAs and the regulation of fibrosis. FEBS J, 2010, 277: 2015-2021.
  • 3Davis BN, Hilyard AC, Lagna G, et al. SMAD proteins control DROSHA-mediated microRNA maturation. Nature, 2008, 454(7200): 56-61.
  • 4Lee SO, Masyuk T, Splinter P, et al. MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease. J Clin Invest, 2008, 118: 3714-3724.
  • 5Dai Y, Sui W, Lan H, et al. Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatol Int, 2009, 29: 749-754.
  • 6Karolina DS, Wintour EM, Bertram J, et al. Riboregulators in kidney development and funetion. Biochimie, 2010, 92: 217-225.

二级参考文献19

  • 1蒋涛,刘国元,赵仲华,张秀荣,张农.TGF-β1对醛糖还原酶在大鼠系膜细胞及人肾小球肾炎中表达的影响[J].复旦学报（医学版）,2004,31(6):565-569. 被引量：13
  • 2Liu Y.Renal fibrosis:new insights into the pathogenesis and therapeutics.Kidney Int,2006,69:213-217.
  • 3Baricos WH,Cortez SL,Deboisblanc M,et al.Transforming growth factor-beta is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells.J Am Soc Nephrol,1999,10:790-795.
  • 4Aplin AE,Howe A,Alahari SK,et al.Signal transduction and signal modulation by cell adhesion receptors:the role of integrins,cadherins,immunogiobulin -cell adhesion molecules,and selectins.Pharmacol Rev,1998,50:197-263.
  • 5Tang K,Wu H,Mahata SK,et al.A crucial role for the mitogen-activated protein kinase pathway in nicotinic cholinergic signaling to secretory protein transcription in pheochromocytoma cells.Mol Pharmacol,1998,54:59-69.
  • 6Jiang T,Che Q,Lin Y,et al.Aldose reductase regulates TGF-beta1-induced production of fibronectin and type Ⅳ collagen in cultured rat mesangial cells.Nephrology(Carhon),2006,11:105-112.
  • 7Ramana KV,Chandra D,Srivastava S,et al.Aldose reductase mediates the mitogenic signals of cytokines.Chem Biol Interact,2003,143-144:587-596.
  • 8Yamamoto T,Noble NA,Cohen AH,et al.Expression of transforming growth factor-beta isoforms in human glomerulAR disease.Kidney Int,1996,49:461-469.
  • 9Wahab NA,Weston BS,Mason RM.Modulation of the TGFbeta/Smad signaling pathway in mesangiai cells by CTGF/CCN2.Exp Cell Res,2005,307:305-314.
  • 10Bottinger EP,Bitzer M.TGF-beta signaling in renal disease.J Am Soc Nephrol,2002,13:2600-2610.

共引文献3

同被引文献70

  • 1Stefani G, Slack FJ. Small non- coding RNAs in animal development. Nat Rev Mol Cell Biol, 2008, 9: 219-230.
  • 2Qian Y, Feldman E, Pennathur S, et al. From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes, 2008, 57: 1439-1445.
  • 3Kato M, Park JT, Natarajan R. MicroRNAs and the glomerulus. Exp Cell Res, 2012, 318: 993-1000.
  • 4Lopez- Hernandez FJ, Lopez- Novoa JM. Role of TGF- beta in chronic kidney disease: an integration of tubular, glomerular and vascular effects. Cell Tissue Res, 2012, 347: 141-154.
  • 5Kato M, Zhang J, Wang M, et aL MicroRNA- 192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E- box repressors. Proc Natl Acad Sei USA, 2007, 104: 3432-3437.
  • 6Kato M, Putta S, Wang M, et al. TGF-beta activates Akt kinase through a microRNA- dependent amplifying circuit targeting PTEN. Nat Cell Biol, 2009, 11: 881-889.
  • 7Wu L, Derynck R. Essential role of TGF- beta signaling in glucose-induced cell hypertrophy. Dev Cell, 2009, 17: 35-48.
  • 8Kattla JJ, Carew RM, Heljic M, et al. Protein kinase B/Akt activity is involved in renal TGF- betal- driven epithelial- mesenchymal transition in vitro and in vivo. Am J Physiol Renal Physiol, 2008, 295: F215-F225.
  • 9Kato M, Yuan H, Xu ZG, et al. Role of the Akt/FoxO3a pathway in TGF- betal- mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. J Am Soc Nephrol, 2006, 17: 3325-3335.
  • 10Kato M, Wang L, Putta S, et al. Post- transcriptional up- regulation of Tsc-22 by Ybxl, a target of miR-216a, mediates TGF- beta- induced collagen expression in kidney cells. J Biol Chem, 2010, 285: 34004-34015.

引证文献4

二级引证文献9

中华肾脏病杂志
2011年 第7期

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