荆花胃康胶丸联合“三联”疗法治疗消化性溃疡疗效观察

Observation on Treating Effect for Peptic Ulcer with JingHua WeiKang Capsules "Triple" Therapy

目的:观察荆花胃康胶丸联合兰索拉唑、呋喃唑酮、阿莫西林"三联"疗法治疗消化性溃疡(PU)的疗效和根除幽门螺旋杆菌(Hp)的效果。方法:将128例幽门螺旋杆菌(Hp)感染阳性消化性溃疡患者随机分为治疗组68例和对照组60例,对照组给予兰索拉唑20mg,2次/d,呋喃唑酮100mg、阿莫西林500mg,均口服,3次/d。治疗组在对照组基础上加服荆花胃康胶丸160 mg,3次/d,口服。2组疗程均为4～8周。观察在治疗前后溃疡愈合率和幽门螺旋杆菌根除情况。结果:治疗组和对照组溃疡愈合率分别为91.2%和88.7%,无显著性差异(P>0.05),幽门螺旋杆菌清除率分别为94.5%和86.7%,有显著性差异(P<0.05)。结论:荆花胃康胶丸联合兰索拉唑、呋喃唑酮、阿莫西林治疗消化性溃疡不仅具有较好的溃疡愈合率而且可提高幽门螺旋杆菌清除率。

Objective：To observe the efficacy of ＂triple＂ therapy for peptic ulcer（PU） with JingHua WeiKang capsules combined lansoprazole,furazolidone,amoxicillin and the effect of eradicating helicobacter pylori （Hp）.Method： 128 patients of peptic ulcer with helicobacter pylori （Hp） infection-positive were randomly divided into two groups,the treatment group had 68 cases and the control group had 60 cases,the control group received lansoprazole 20rag,2 times 1 day, orally;furazolidone 100mgc4Mo XiLin 500 mg,3 times 1 day, orally.Based on the control group, the treatment group were added JingHua WeiKang capsules,160 rag,3 timeslday, orally.A course contained 6--8 weeks.Observed the situation of ulcer healing rate and H.pylori eradication rate between two groups before and after treatment.Result：The ulcer healing rate of the treatment group and the control group were 91.2% and 88.7%,no significant difference（P〉0.05）, the H. pylori eradication rates were 94.5% and 86.7%,had significant difference （P〈0.05）.Conclusion：The treatment for peptic ulcer with JingHua WeiKang capsules combined lansoprazole,furazolidone,amoxicillin not only has a better ulcer healing rate,also can increase the H. Pylori clearance rate, this therapy is effective and worthy to be popularized in clinical.