摘要
目的通过检测急性脑梗死(acute cerebral infarction,ACI)患者血清高迁移率族蛋白B1(high mobil-ity group box 1,HMGB1)水平的变化,探讨HMGB1与ACI病情的关系。方法测定128例ACI患者、46名健康对照者血清HMGB1水平,观察比较ACI患者在不同病情、不同梗死面积时血清HMGB1水平的变化,对发病后48h病情发展变化进行评定,根据评分结果分为进展型与完全型脑梗死两组进行观察比较。结果 ACI患者血清HMGB1水平〔(9.05±2.03)μg/ml〕明显高于健康对照组〔(1.07±0.59)μg/ml〕,且HMGB1水平随神经功能缺损程度评分增高亦明显升高;进展性脑梗死患者血清HMGB1水平明显高于非进展性患者。结论 HMGB1一定程度上是预测ACI患者病情严重程度及进展的相关生化指标之一。
Objective To investigate the change and its significance of high mobility group box 1（HMGB1）in patients with acute cerebral infarction（ACI）.Methods The content of serum HMGB1 in 128 patients with ACI and 46 normal control were measured.The changes of HMGB1 were compared with patients of different pathogenetic condition and infarction areas.The disease progress were evaluated in 48 h after cerebral ischemic stroke.The patients were divided into progressive stroke and complete stroke.Results The level of HMGB1 in patients with ACI increased significantly comparing with control group.The level of serum HMGB1 was increasing with scores of neurofunction detected and extensions of the infarction area.The serum 1evels of HMGB1 in the progressive group were significantly higher than that in the complete group.Conclusion The HMGB1 could be one of the indexes to predict the prognosis of ACI.
出处
《实用心脑肺血管病杂志》
2011年第8期1279-1280,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
急性脑梗死
高迁移率族蛋白B1
Acute cerebral infarction
High mobility group box 1
