慢性充血性心力衰竭的氨基酸疗法研究

The Effect of Amino Acids Treatment on Patients with Chronic Congestive Heart Failure

目的研究口服L-精氨酸和瓜氨酸对慢性充血性心力衰竭病人内皮功能的影响。方法用光电体积描记术记录30例确诊病人示指脉搏波。测定口服L-精氨酸和瓜氨酸试验前后静息状态下脉搏波和缺血后每30s时间段的最大脉搏波时长、总时长以及两者之间的比值。结果两组受试者试验前脉搏波无明显差异。口服氨基酸后,每30s时间段的最大脉搏波时长/总时长比值较试验前均有显著差异,试验前后静息状态下脉搏波,L-精氨酸组(38.75±11.52 vs 23.32±6.08,P=0.007)和瓜氨酸组(41.4±13.47 vs 23.65±6.74,P=0.007)。试验前后60～90s时间段,L-精氨酸组(36.60±11.51 vs 18.81±15.13,P=0.004)和瓜氨酸组(49.51±15.17 vs 27.13±7.87,P=0.003)。结论 口服L-精氨酸和瓜氨酸有助于改善内皮功能,减低血压和肺动脉收缩压,辅助治疗慢性充血性心力衰竭。

Objective Study effect of L-arginine and citrulline on endothelial function in patients with chronic congestive heart failure.Methods 30 subjects confirmed diagnosis of chronic congestive heart failure were recorded index finger pulse wave by photoplethysmography.Then,the data about basal and each 30 s intervals by maximum amplitude time,total time and the ratio of the two before and after the administration of L-arginine or citrulline for two months were measured.Results There were no statistically significant differences of the basal data between the two groups before the administration of L-arginine or citrulline.However,after the administration,the ratio of maximum amplitude time/total time was significant lower than that basal data.In L-arginine group（38.75±11.52 vs 23.32±6.08,P=0.007） and citrulline group（41.4±13.47 vs 23.65±6.74,P=0.007）.At 60～90s interval,L-arginine group（36.60±11.51 vs 18.81±15.13,P=0.004）,and citrulline group（49.51±15.17 vs 27.13±7.87,P=0.003）.Conclusion There was an advantageous influence on endothelial function by taking L-arginine and citrulline orally.It may reduce blood pressure and improve pulmonary hemodynamics in favor of the treatment of chronic congestive heart failure.