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反应停对胆囊癌细胞的作用机制研究

Mechanisms of Thalidomide Action in Gallbladder Cancer Cells
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摘要 目的初步探讨反应停对胆囊癌细胞的作用机制。方法应用RT-PCR技术检测经反应停处理后胆囊癌细胞株GBC-SD中survivin、VEGF、MMP-9的表达。结果 survivin、VEGF、MMP-9在经反应停处理的人胆囊癌细胞株GBC-SD中表达下降,且与反应停的浓度有关。结论反应停可能通过促进细胞凋亡和抑制血管生成等机制作用于胆囊癌细胞。 Objective To investigate the mechanisms of Thalidomide action in gallbladder cancer（GBC） cells.Methods RT-PCR was employed to examine the expression of survivin,VEGF and MMP-9 in GBC-SD cells.Results The expression of survivin,VEGF and MMP-9 in GBC-SD cells was decreased by Thalidomide,and the expression was related to the concentration of Thalidomide.Conclusion Thalidomide can inhibit the growth of GBC cells by inducing cell apoptosis and inhibiting angiogenesis.
作者 朱国民 钟德玝 李学明 万平
机构地区 南昌大学第一附属医院普外一科 中南大学附属第二医院普外科
出处 《实用临床医学（江西）》 CAS 2011年第5期1-3,7,共4页 Practical Clinical Medicine
关键词 反应停 胆囊癌细胞 SURVIVIN VEGF MMP-9 Thalidomide gallbladder cancer cells surviving VEGF MMP-9
分类号 R735.8 [医药卫生—肿瘤]
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参考文献20

  • 1Rubegni P,Sbano P,De Aloe G,et al. Thalidomide in the treatment of Kaposi ' s sarcoma [J ]. Dermatology, 2007,215 ( 3 ) : 240-244.
  • 2Ben M' barek L, Fardet L, Mebazaa A. A retrospective analysis of thalidomide therapy in non-HIV-related Kaposi' s sarcoma[J]. Dermatology,2007,215(3) :202-205.
  • 3Radocha J, Maisnar V. Low-dose thalidomide in refractory and relapsing multiple myeloma[J]. Vnitr Lek, 2007,53 (2) : 129- 134.
  • 4Raina V, Sengar M, Shukla N K, et al. Complete response from thalidomide in angiosarcoma after treatment of breast cancer [J]. J Clin Oneol,2007,25(7) :900-901.
  • 5Efstathiou E, Troncoso P, Wen S, et al. Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer[J]. Clin Cancer Res, 2007,13(4);1224- 1231.
  • 6Vaishampayan U N,Heilhrun L K,Shields A F,et al. Phase Ⅱ trial of interferon and thalidomide in metastatic renal cell carci- noma[J]. Invest New Drugs,2007,25(1) :69-75.
  • 7张翠卿,唐东平,佐传田,祝家兴,贺海平.MTT法在非小细胞肺癌优化治疗方案中的应用[J].现代肿瘤医学,2007,15(11):1566-1568. 被引量：5
  • 8GOmez Roel X, Arrieta O, LeOn Rodriguez E. Prognostic fac tors in gallbadder and biliary tract cancer[J]. Med Oneol, 2007,24(1) :77-83.
  • 9Grzybowska Izydorczyk O,Smolewski P. The role of the inhib- itor of apoptosis protein (IAP) family in hematological malig nancies[J]. Postepy Hig Med Dosw, 2008, 14 (62) : 55-63,.
  • 10Tabuchi K,Pak K,Chavez E, et al. Role of inhibitor of apop- tosis protein in gentamicin-induced cochlear hair cell damage [J]. Neuro Science,2007,149(1) : 213-222.

二级参考文献31

  • 1Jian-JunLi,YingChen,Su-MinZhang,Dong-YingWu,Yan-PingWang,YanXin.Pathobiological significance of vascular endothelial growth factor and Maspin expressions in human gastric carcinoma[J].World Journal of Gastroenterology,2004,10(18):2624-2627. 被引量：7
  • 2辛华雯,王润帮,杜光祖.MTT法在恶性肿瘤体外药物敏感试验中的临床应用[J].实用癌症杂志,1994,9(2):73-75. 被引量：25
  • 3De Vita VT Jr, Hellmau S, Rosenberg SA. Cancer:principles and practice of oncology( Sixth edition) [M]. Philadelphia:JB Lippincott,2001.21-22.
  • 4Levi F. From circadian to cancer chronotherapeutics[J]. Chronobiology International,2002,19( 1 ) : 1-19.
  • 5Bellamy WT. Prediction of response to drag therapy of cancer:a review of in vitro assays[J]. Drags, 1992,44:690.
  • 6Oka M, Fukuda M. Phase I study of irinotecan and cisplatin with concurrent split -course radiotherapy in unresectable arid locally advanced non - small cell lung cancer[J]. Eur J Cancer,2001,37 (11) :1359-1365.
  • 7Sargent JM. The use of the MTT assay to study drug resistance in fresh tumour samples[J]. Recent Resuhs Cancer Res,2003,161 : 13-25.
  • 8Kaspers GJL,Veerman AJP,Pieters R,et al. Drag combination testing in acute lymphoblastic leukemia using the MTT assay [J]. Leuk Res, 1995,19 : 175-183.
  • 9Fruehauf JP, Alberts DS. In vitro drug resistance versus chemosen- sitivity:Two sides of different coins [J]. J Clin Oncol, 2005,23 (15) :3641-3643.
  • 10Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med, 1997,3(8) :917 -921.

共引文献13

实用临床医学（江西）
2011年 第5期

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