应用受试者工作特征曲线评价甲胎蛋白、α-L-岩藻糖苷酶、CA199及γ谷氨酰转移酶检测对原发性肝癌的诊断价值

Diagnostic Values of AFP,AFU,CA199,and GGT Detection in Primary Hepatic Carcinoma Assessed by ROC Curve

目的评价甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、CA199、γ谷氨酰转移酶(GGT)检测对原发性肝癌(PHC)患者的诊断价值。方法选取40例原发性肝细胞癌患者(肝癌组)、40例慢性肝炎患者(慢性肝炎组)和40例健康体检者(对照组),检测3组受试者血清中AFP、AFU、CA199、GGT的水平,比较检测阳性率。应用受试者工作特征(ROC)曲线对AFP、AFU、CA199、GGT检测结果进行分析评价。结果肝癌组患者血清AFP、AFU、CA199、GGT检测阳性率分别是87.5%、82.5%、60.0%和87.5%,均显著高于慢性肝炎组和对照组,差异有统计学意义(P<0.01)。AFP、AFU、CA199、GGT对PHC的诊断临界点分别为0.025 mg/L、32 U/L、37 U/ml、40U/L,PHC患者的AFP、AFU、CA199、GGT检测在ROC曲线下面积分别为0.973、0.966、0.754和0.948。结论通过ROC曲线评价,各指标诊断PHC的效能如下:AFP>AFU>GGT>CA199。

Objective To study the diagnostic values of AFP,AFU,CA199,and GGT in primary hepatic carcinoma（PHC）.Methods The levels of serum AFP,AFU,CA199,and GGT in 40 PHC patients,40 chronic hepatitis B,and 60 healthy controls were retrospectively analyzed and evaluated using ROC curve.Results Significant differences existed among the three groups（P=0.000）.The positive rates of AFP,AFU,CA199,and GGT in the PHC group were 87.5%,82.5%,60.0%,and 87.5% respectively.Diagnosis critical point of AFP,AFU,CA199,and GGT in PHC were 0.025 mg/L,32 U/L,37 U/ml,and 40 U/L.The area under ROC curve of AFP,AFU,CA199,and GGT among the PHC patients were 0.973,0.966,0.754,and 0.948 respectively.Conclusion The diagnostic value of AFP is the best among the assessed molecules,with AFU and GGT ranking the second and the third,respectively.