初发2型糖尿病患者血浆内脂素水平的变化

Change of plasma visfatin level in newly diagnosed type 2 diabetic patients

目的探讨初发2型糖尿病(T2DM)患者血浆内脂素水平的变化及其与糖、脂代谢的相关性。方法采用ELISA法检测106例内分泌科住院的初发T2DM患者(T2DM组)和100例健康体检者(对照组)的血浆内脂素水平,同时检测2组患者血糖、血脂代谢参数水平。通过单因素直线相关分析及多元线性逐步回归分析探讨血浆内脂素水平与糖脂代谢指标的关系。结果 T2DM组体质指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、内脂素均高于对照组(P均<0.01)。单因素直线相关分析显示,T2DM患者血浆内脂素水平分别与WHR(r=0.489,P<0.01)、BMI(r=0.226,P<0.01)、FPG(r=0.345,P<0.01)、HbA1c(r=0.186,P<0.05)、HOMA-IR(r=0.215,P<0.01)呈正相关,而与性别、年龄、TC、TG、LDL-C、HDL-C、FINS无相关性(P均>0.05)。多元线性逐步回归分析显示,WHR和FPG是影响血浆内脂素水平的独立相关因素。结论血浆内脂素水平变化与糖、脂代谢关系密切,它可能在T2DM的发病机制中起着一定作用。

Objective To investigate the change of plasma visfatin level in newly diagnosed type 2 diabetic patients.Methods A total of 106 patients with newly diagnosed type 2 diabetes （T2DM） hospitalized （T2DM group） and 100 healthy subjects （control group） were enrolled in this study.Plasma visfatin level was assayed by enzyme-linked immunosorbent assay, and meanwhile the metabolic parameters levels of blood glucose and lipid were measured for each participant.Univariate linear correlation analysis and Multivariate linear stepwise regression analysis were performed to determine the association between level of visfatin and indexes of glycolipid metabolism.Results The body mass index （BMI）,waist to hip ratio （WHR）, fasting plasma glucose （FPG）, glycosylated hemoglobin （HbA1c）,fasting insulin （FINS）, insulin resistance index （HOMA-IR）,triglyceride （TG） and visfatin level in T2DM group were all higher than those in control group （all P0.01）. Univariate linear correlation analysis showed that the level of visfatin in T2DM group was positively correlated with WHR（r=0.489,P0.01）, BMI（r=0.226,P0.01）,FPG（r=0.345,P0.01）,HbA1c（r=0.186,P0.05）, HOMA-IR（r=0.215,P0.01）, and had no correlation with gender,age,TC, TG, LDL-C,HDL-C and FINS （all P0.05）.Multivariate linear stepwise regression analysis showed that WHR and FPG were the independent risk factors affecting plasma visfatin level.Conclusions Plasma visfatin level has close relationship with glycolipid metabolism, and it may play a role in pathogenesis of T2DM.