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肺癌患者FHIT基因突变及其与吸烟、化疗敏感性的关系 被引量：1

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摘要 脆性组氨酸三联体（FHIT）基因是Ohta等〔1〕于1996年在3p14.2上找到的一种新的抑癌基因,在肺癌发生中起重要作用,在吸烟者中这种作用更加明显,其低表达可促进肺癌的发生和发展,影响某些化疗药物敏感性,并具有预后评估价值。FHIT基因包括t（3;8）断裂点、FRA3B及HPV16整合位点,在染色体上占据了约2Mb的位置。
作者 马列 赵明静 王群 王笑歌
机构地区 中国医科大学附属第四院呼吸内科
出处 《中国临床研究》 CAS 2011年第7期637-638,共2页 Chinese Journal of Clinical Research
基金 国家科技支撑计划项目(2007BAI24B04) 中华医学会基金项目(070103200400 07010250033 08020680146) 辽宁省教育厅资助项目(05L4692009A760) 辽宁省科技厅自然基金项目(20092097)
关键词 肺癌 FHIT基因 基因突变 吸烟 化学治疗
分类号 R734.2 [医药卫生—肿瘤]
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参考文献16

  • 1Ohta M,Inoue H,Cotticelli MG,et al. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3 ; 8 ) breakpoint, is abnormal in digestive tract cancers[J]. Cell, 1996,84(4) :587 -597.
  • 2Sozzi G, Veronese ML, Negrini M, et 81. The FHIT gene at 3 p14.2 is abnormal in lung cancer[ J]. Cell, 1996,85 ( 1 ) : 17 - 26.
  • 3Wali A, Srinlvasan R, Shabnam MS, et al. Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allel- ic loss at 3 p 14 locus and promoter methylation [J]. Mol Cancer Res, 2006,4(2) :93 -99.
  • 4Tseng JE, Kemp BL, Khuri FR, et al. Loss of Fhit is frequent in stage I non-small cell lung cancer and in the lungs of chronic smok- ers [J]. Cancer Res, 1999,59 ( 19 ) :4798 - 4803.
  • 5Barnes LD, Garrison PN, Siprashrili Z, et al. Fhit a putative tumor suppressor in humans, is a dinucleside 5' ,5"'-PI, P3-triphosphate hydrolase [J]. Biochemistry, 1996,35 (36) : 11529 - 11535.
  • 6Tomizawa Y, Nakajiwa T, Kohno T, et al. Cllniopathological signifi- cance of FHIT protein expression in stage 1 non-sma/l ceU lung car- cinoma[J]. Cancer Res, 1998,58(23 ) :5478 - 5483.
  • 7C, cradts J, Fong KM, Zimmerman PV, et al. Loss of Fhit expression in non-small -cell lung cancer: correlation with molecular genetic ab- normalities and clinicopathological features[J].Br J Cancer,2000, 82(6) :1191 - 1197.
  • 8Allain LR, Askari M, Stokes DL, et al. Mieroarray sampling-platform fabrication using bubble-jet technology for a biochip system[J]. Fr- esenius J Anal Chem,2001,371 (2) : 146 - 150.
  • 9Dumon KR, Ishii H, Fong LY, et al. FHIT gene therapy prevents tumor development in Fhit-detleient mice [J]. Prec Natl Acad Sci USA,2001,98(6) :3346 -3351.
  • 10Ji L, Fang B, Yen N, et al. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovims vector-mediated frag- ile hlstldine triad ( FHIT ) gene overexpression Cancer Res, 1999,59 (14) :3333 - 3339.

二级参考文献8

  • 1张生军,张才全.FHIT基因结构、功能及其应用研究进展[J].重庆医学,2004,33(9):1411-1413. 被引量：6
  • 2Ohta M,Inoue H,Cotticelli MG,et al.The FHIT gene,spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint,is abnormal in digestive tract cancers[J].Cell,1996,84:587-597.
  • 3Wali A,Srinivasan R,Shabnam MS,et al.Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation[J].Mol Cancer Res,2006,4:93-99.
  • 4Tseng JE,Kemp BL,Khuri FR,et al.Loss of Fhit is frequent in stage Ⅰ non-small cell lung cancer and in the lungs of chronic smokers[J].Cancer Res,1999,59:4798 -4803.
  • 5Toledo G,Sola JJ,Lozano MD,et al.Loss of FHIT protein expression is related to high proliferation,low apoptosis and worse prognosis in non-small-cell lung cancer[J].Mod Pathol,2004,17:440-448.
  • 6Geradts J,Fong KM,Zimmerman PV,et al.Loss of Fhit expression in non-small-cell lung cancer:correlation with molecular genetic abnormalities and clinicopathological features[J].Br J Cancer,2000,82:1191-1197.
  • 7Ji L,Fang B,Yen N,et al.Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression[J].Cancer Res,1999,59:3333-3339.
  • 8王国付,沈荣林,刘敬东.肺癌组织中FHIT基因蛋白的表达缺失与吸烟的关系[J].肿瘤学杂志,2002,8(2):73-75. 被引量：6

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中国临床研究
2011年 第7期

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