内源性睡眠促进物质研究进展

Endogenous sleep-promoting substances

睡眠和觉醒的发生及转换可能是脑内神经递质和内源性睡眠促进物质共同作用的结果,同时受昼夜节律调控。Ishimori和Piéron首次发现犬睡眠剥夺后,脑脊液中某种化学物质增多,诱发睡眠,并将其命名为促眠素,即内源性睡眠促进物质。目前已发现前列腺素D2、核苷、细胞因子、神经肽、激素、胺类衍生物及一氧化氮等二十多种内源性睡眠促进物质。本文综述前列腺素D2、腺苷、白细胞介素1和肿瘤坏死因子等调节睡眠的作用机制研究进展。

Sleep-wake cycle is regulated by humoral and neuronal mechanism,as well as circadian rhythm.Kuniomi Ishimori and Henri Piéron provided the first experimental evidence for chemical factors that presumably accumulate in the cerebrospinal fluid in dogs after sleep deprivation,and eventually induce sleep.These substances are named hypnotoxin.Accumulated findings show that these endogenous substances include prostanoids,nucleotides,cytokines,neuropeptides,hormones,amine derivatives,nitrogen oxide and so on.This paper presents an overview of current knowledge about the roles of endogenous sleep-promoting substances in the sleep-wake regulation with a focus on prostaglandin D2,adenosine,interleukin-1,and tumor necrosis factor.