模型动物失神经支配及神经肌肉电刺激的可编程植入式神经肌肉电刺激器

A programmable and implantable neuromuscular electrical stimulator for denervated or neuromuscular electrical stimulation in animal models

背景:植入式神经肌肉电刺激器可用于研究功能性电刺激对动物失神经肌肉的作用机制,但体积偏大,功能单一。目的:设计一种微型、参数可调的植入式神经肌肉电刺激器。方法:基于红外通信技术,以MSP430为控制核心,采用低功耗设计,经体外控制器设置参数,产生电荷平衡的双相脉冲序列,可对神经或肌肉进行电刺激。结果与结论:实验设计的刺激器可在体编程,能够灵活设置刺激电压幅值、频率、脉宽和间隔时间等参数。多参数的设置丰富了刺激协议选择性,可最小化对目标神经肌肉临近组织的不可预测刺激,优化了功耗设计,可确保实验动物的安全性。

BACKGROUND： Implantable neuromuscular electrical stimulator is a useful tool for the study how functional electrical stimulation works on denervated muscle. However, its volume is a little big and the function is single. OBJECTIVE： To design an implantable micro-stimulator featuring adjustable parameters which can reach the requirement of animal pattern experiment through test and analysis. METHODS： Based on infrared communication technology, taking MSP430 as controller and setting stimulation parameters by controller in vitro, it generates charge balanced bipolar pulses, and stimulates nerve or muscle via electrodes. RESULTS AND CONCLUSION： The stimulator is programmable in vivo and all parameters, such as voltage amplitude, frequency, pulse width and rest time of the stimulation, can be set and changed flexibly. It enriches selectivity of stimulating protocol by setting parameters, so that the unpredictable stimulation to the tissue around the target neuromuscular is minimized, the design of current consumption is optimized and the safety of experimental animals is ensured.