八角茴香提取液的抗疲劳效应

Anti-fatigue effects of Fructus Anisi Stellati extract

背景:延缓疲劳或消除疲劳是运动医学的研究热点,利用中药来消除运动性疲劳,提高机体运动能力,具有重要应用前景。目的:观察八角茴香提取液对小鼠的抗疲劳作用。方法:将120只雄性昆明种小鼠按体质量随机分为4组:分别给予21,42,84mL/(kgd)的八角茴香提取液和蒸馏水,35d后,检测小鼠力竭游泳时间、爬杆时间及运动后血乳酸水平;40d后,检测小鼠运动后肝糖原含量、血清尿素氮和乳酸脱氢酶活力。结果与结论:八角茴香提取液可增加小鼠力竭游泳时间、爬杆时间及运动后肝糖原含量,提高运动后小鼠血乳酸脱氢酶活力,同时降低小鼠运动后血乳酸及尿素氮水平,尤以84mL/(kgd)八角茴香提取液的效果最明显(P<0.05或P<0.01)。说明八角茴香提取液有明显的抗疲劳作用。

BACKGROUND：Delay fatigue or fatigue elimination are the research focuses in the sports medicine.It has great prospect to utilize traditional Chinese drug to eliminate sports fatigue and increase sports ability.OBJECTIVE：To study the antifatigue effects of Fructus Anisi Stellati on mice.METHODS：Based on body weight,120 male Kunming mice were randomly divided into 4 groups,which given 21,42,84 mL/（kg ·d） Fructus Anisi Stellati extract or distilled water.Exhaustive swimming time,pole-climbing time and post exercise lactate level were detected at 35 days after medication.Post exercise hepatic glycogen content,serum urea nitrogen and lactate dehydrogenase activity were determined at 40 days after medication.RESULTS AND CONCLUSION：The Fructus Anisi Stellati could increase exhaustive swimming time,pole-climbing time and post exercise hepatic glycogen content,raise lactate dehydrogenase activity,decline lactate and serum urea nitrogen levels,the effectiveness was most manifest in the 84 mL/（kg·d） group （P〈0.05 or P〈0.01）.The findings demonstrated that Fructus Anisi Stellati has noticeable antifatigue effect on mice.