采用HA130型树脂灌流器血液灌流对维持性血液透析患者微炎症的影响

Effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in maintenance hemodialysis patients

背景:研究发现维持性血液透析的尿毒症患者体内存在"微炎症状态"。目的:观察采用HA130型树脂灌流器行血液灌流对维持性血液透析患者微炎症的影响。方法:选取维持性血液透析治疗的尿毒症患者60例,随机分为2组,灌流组采用HA130型树脂灌流器串联血液透析器进行血液灌流加血液透析治疗;透析组行单纯血液透析治疗。采集治疗前后两组患者的血清,检测高敏C-反应蛋白、肿瘤坏死因子α和白细胞介素6水平。结果与结论:灌流组血清高敏C-反应蛋白、白细胞介素6和肿瘤坏死因子α水平治疗后较治疗前显著降低(P<0.05);透析组治疗后上述指标较治疗前略升高,差异无显著性意义。提示血液灌流可以降低维持性血液透析患者血清高敏C-反应蛋白、白细胞介素6和肿瘤坏死因子α水平,有利于减轻其微炎症反应。

BACKGROUND：Studies have found that the microinflammatory state exists in uremic patients undergoing maintenance hemodialysis（MHD）.OBJECTIVE：To investigate the effects of hemoperfusion using HA130 resin hemoperfusion apparatus on microinflammatory state in MHD patients.METHODS：Sixty uremia patients undergoing maintenance hemodialysis were divided into two groups：hemoperfusion group（n=30） and MHD group（n=30）.Hemoperfusion group underwent the treatment of hemoperfusion using HA130 resin hemoperfusion apparatus combined with hemodialysis.MHD group underwent the treatment of hemodialysis.The serum levels of high-sensitivity C-reactive protein（hs-CRP）,interleukin-6（IL-6） and tumor necrosis factor alpha（TNF-α）of all patients in the two group were detected before and after the treatment.RESULTS AND CONCLUSION：In the hemoperfusion group,the serum levels of hs-CRP,IL-6 and TNF-α were lower after treatment than those before treatment,and the difference was significant（P0.05）;In the MHD group,the serum levels of hs-CRP,IL-6 and TNF-α were higher after treatment than those before treatment,and the difference was not significant（P0.05）.The results indicate that hemoperfusion using HA130 resin hemoperfusion apparatus can reduce the serum levels of hs-CRP,IL-6 and TNF-α and control the microinflammatory state in MHD patients.