幽门螺杆菌感染与小儿再发性腹痛的Meta分析

Meta-Analysis of the Relationship Between the Infection of Helicobacter Pylori and Recurrent Abdominal Pain in Children

目的:综合分析幽门螺杆菌(Hp)感染与小儿再发性腹痛(RAP)的关系。方法:计算机检索1999年9月至2009年9月国内外期刊网数据库,纳入Hp感染与小儿再发性腹痛关系的病例-对照研究,用Meta分析方法对数据进行处理,估计其综合OR值和95%CI。结果:共纳入23篇文献,包括3 496例病例组和2 487例对照组。Meta分析显示Hp感染与小儿再发性腹痛的关联性有统计学意义[OR合并=2.65,95%CI(2.05,3.43)];Hp感染与RAP患儿年龄的关联性有统计学意义[OR合并=0.71,95%CI(0.52,0.97)];与RAP患儿的性别及父母文化程度的关联性则无统计学意义,其OR合并分别是1.05,1.18,95%CI分别是(0.84,1.32),(0.73,1.90);Hp根治与RAP患儿腹痛缓解的关联性有统计学意义[OR合并=16.65,95%CI(10.01,27.69)]。结论:Hp感染是小儿再发性腹痛发生的重要危险因素之一。年龄较大的儿童更容易因Hp感染导致腹痛。Hp根除治疗可以显著缓解部分再发性腹痛患儿的腹痛症状。

Objective：To analyze the relationship between the infection of Helicobacter pylori（Hp） and recurrent abdominal pain in children.Methods：Researches on the relationship between Hp infection and recurrent abdominal pain in children were selected in both domestic and international periodical databases between September,1999 and September,2009.Combined odd ratio（OR） value and 95% confidence interval（CI）were calculated.Results：Twenty-three literatures were reviewed and analyzed,which included 3 496 children with recurrent abdominal pain and 2 487 children without recurrent abdominal pain as control group.Meta analysis reveal the relevance between Hp infection and children＇s recurrent abdominal pain had statistical significance（OR combine = 2.65,95%CI=2.05-3.43）.Among of these,the relevance between Hp infection and the age of children had statistical significance（OR combine=0.71,95%CI=0.52-0.97）,and the relevance between Hp infection and the gender of these children or the parents＇ educational background had no statistical significance（OR combine=1.05,95%CI=0.84-1.32;OR combine=1.18,95%CI=0.73-1.90,respectively）.The relevance between radical treatment of Hp and the relief of recurrent abdominal pain in children had statistical significance（OR combine=16.65,95%CI=10.01-27.69）.Conclusion：Hp infection is an important risky factor of children＇s recurrent abdominal pain.The older children are more susceptible to have recurrent abdominal pain with Hp infection,and the eradication of Hp can remarkably relieve the recurrent abdominal pain in children.