血浆蛋白Z与急性缺血性脑卒中的相关性

Relationship Between Plasma Protein Z Levels and Acute Ischemic Stroke

目的:探讨急性缺血性脑卒中(AIS)患者血浆蛋白Z(PZ)水平变化及临床意义。方法:采用病例-对照的研究方法,随机选取88例缺血性脑卒中患者及同期84例健康体检者。AIS患者均为急性期(发病后1-3d)取静脉血。以酶联免疫吸附法(ELISA)检测各组中血浆中PZ的含量。根据头部核磁共振(MRI)结果将AIS患者分为两组:皮质动脉卒中组和穿通动脉卒中组。结果:急性缺血性脑卒中患者血浆PZ水平明显高于健康对照组(P<0.01)。穿通动脉卒中组血浆PZ水平明显低于皮质动脉卒中组(P<0.05),而与健康对照组差异无显著性(P>0.05)。结论:血浆PZ水平明显增高是缺血性脑卒中的危险因素,提示血浆PZ水平增高可能在皮质动脉卒中发病中起到一定的作用。

Objective：To investigate the correlation among levels of plasma protein Z and acute ischemic Stroke.Methods：A total of 88 cases of acute ischemic stroke and 84 healthy controls were enrolled in this study.Plasma protein Z concentrations were measured within three days after acute ischemic stroke by enzyme-linked immunosorbent assay（ELISA）.According to the established MRI criteria,the acute ischemic stroke group were classified into two subtypes as cortical artery occlusion（CAO） group and perforating artery occlusion（PAO） group.Results：Plasma levels of protein Z measured within 72 h after acute ischemic stroke were significantly higher in acute ischemic stroke cases than in controls（P0.01）,and were much lower in PAO group than in the CAO group（P0.05）,but no difference was found between PAO group and control group（P0.05）.Conclusion：Significantly increased plasma levels of protein Z may be a risk factor for acute ischemic stroke,especially for the occurrence of CAO.