单纯口服避孕药用于原发性痛经的临床疗效

Clinical Aplication of Simple Oral Contraceptive in the Treatment of Primary Dysmenorrhea

目的:研究单纯口服避孕药(妈富隆)治疗原发性痛经的效果。方法:收集我院门诊及病房原发性痛经患者35例、对照组(体检正常健康组)30例,痛经组及对照组均随机分为2个亚组,分别给予口服避孕药和安慰剂(维生素E)治疗。接受试验时收集患者月经血以及采集静脉血。治疗时间均为3个月经周期。检测月经血中前列腺素(PGE2、PGF2α)水平以及月经期静脉血中PGE2、PGF2α表达水平。结果:痛经组月经血中以及静脉血中前列腺素水平均高于正常对照组,经3个月经周期口服避孕药治疗后,痛经组口服避孕药后月经血及静脉血中PGE2、PGF2α水平均明显低于治疗前水平,差异有统计学意义;对照组口服避孕药后月经血中以及静脉血中前列腺素水平也低于对照组未口服避孕药组,差异有统计学意义。结论:口服避孕药能够降低原发性痛经患者前列腺素水平。对原发性痛经有一定治疗作用。

Objective：To study the simple oral contraceptive（mawelon） in the treatment of primary dysmenorrhea treatment effect,and to investigate the changes of prostaglandins（PGE2,PGF2 alpha） levels in menstrual blood and in peripherial blood.Methods：Thirty-five cases of primary dysmenorrhea and 30 healthy subjects（control group） were included in this study,and both groups were sub-divided into a contraceptive group and a placebo（Vitamine E） group respectively.The clinical effect was analyzed,and prostaglandins levels in menstrual blood and in peripherial blood were compared.Results：The levels of prostaglandins in menstrual blood and in peripherial blood were higher in dysmenorrhea group than in cntrol group.After three menstrual cycles of simple oral contraceptive treatment,the levels of prostaglandins in menstrual blood and in peripherial blood were decreased both in dysmenorrhea group and in control group.And the clinical effective rate was higher in dysmenorrhea group versus that in control group.Conclusion：Oral contraceptives can reduce the prostaglandin level and is effective for the primary dysmenorrhea patients.